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首页> 外文期刊>Comparative Medicine >A Nonlethal Young Domesticated Ferret (Mustela putorius furo) Model for Studying Pandemic Influenza Virus A/California/04/2009 (H1N1)
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A Nonlethal Young Domesticated Ferret (Mustela putorius furo) Model for Studying Pandemic Influenza Virus A/California/04/2009 (H1N1)

机译：研究大流行性流感病毒A /加利福尼亚的非致命性年轻驯化雪貂（Mustela putorius furo）模型/加利福尼亚/ 04/2009（H1N1）

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RecenteventshaveheightenedtheneedfortherapiddevelopmentofvaccinesdirectedagainstpandemicinfluenzaH1N1virusescirculatingduring2009to2010.ThecurrentstudywasconductedtoestablishaviruschallengedoseforasubsequentCA/04vaccineefficacystudyin3-mo-olddomesticatedferrets.AnadditionalconsiderationinusingCA/04inferretsistheselectionofendpointsonwhichtobasethechallengedose,giventhepotentialnonlethalityofthisparticularmodel.Fourdosesrangingfrom10supxmlns="http://pub2web.metastore.ingenta.coms/"4/supto10supxmlns="http://pub2web.metastore.ingenta.coms/"7/supTCIDsubxmlns="http://pub2web.metastore.ingenta.coms/"50/subunitsofCA/04peranimalwereadministeredbyintranasalinstillationtogroupsofmaleandfemaleferrets,andvirustitersinnasalwashesobtained1,3,and5dthereafterweredeterminedinMDCKcells.Dosedferretsdevelopedclinicallymildinfections.Peakvirustitersoccurredonday3afterinstillationregardlessofdose.Virus-treatedferretshadlessweightgainthandiduntreatedferrets.Inconclusion,3-mo-oldferretscanbeinfectedwithdosesaslowas10supxmlns="http://pub2web.metastore.ingenta.coms/"4/supTCIDsubxmlns="http://pub2web.metastore.ingenta.coms/"50/subunitsofCA/04,andvirustitersinnasalwashesanddecreasedbodyweightgaincanbeusedtoassessthecourseofnonlethalinfectionof3-mo-oldferretsbyCA/04.
机译：RecenteventshaveheightenedtheneedfortherapiddevelopmentofvaccinesdirectedagainstpandemicinfluenzaH1N1virusescirculatingduring2009to2010.ThecurrentstudywasconductedtoestablishaviruschallengedoseforasubsequentCA / 04vaccineefficacystudyin3-MO-olddomesticatedferrets.AnadditionalconsiderationinusingCA / 04inferretsistheselectionofendpointsonwhichtobasethechallengedose，giventhepotentialnonlethalityofthisparticularmodel.Fourdosesrangingfrom10 4 至10 7 TCID 50 单位CA / 04peranimal，通过雌雄同体的雄性和雌性雪貂进行管理，并从鼻腔清洗获得病毒滴定液1 3，然后再清除5种MDCK细胞。加药的雪貂临床上出现了轻度感染。滴注后第3天出现峰病毒滴度，不论剂量如何。病毒处理过的雪貂体重减轻了一半，未处理过的雪貂。结论是，3-mo年老的雪貂可以扫描allowedwithsesaslowas10 4 TCID 50 CA / 04的单位，并可以通过鼻洗洗液和减少体重增加来评估CA / 04对3个月大雪貂的非致死性感染过程。

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