Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats

Booth Carmen J; Brooks Marjory B; Rockwell Sara

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Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats

机译：自交WAG / RijYcb大鼠自发性凝血

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HerewedescribeaseriesofcasesofspontaneouscoagulopathyinacolonyofinbredWAG/RijYcb(WAG/RijY)rats.Thisstrainpreviouslyhadbeenbredatourinstitutionwithoutsymptomatologyforseveraldecades.Theindexcasewasa10-wk-oldmaleratthatdevelopedalargehematomaatasubcutaneousinjectionsite.ClinicopathologicfindingsincludedadecreasedRBCcount,decreasedhematocrit,decreasedhemoglobinconcentration,normalPT,andprolonged(50%to70%)aPTT(52s;reference,15to33s).ExaminationofadditionalWAG/RijYratsthatdiedunexpectedlyorhadclinicalsignsofbleedingintheabsenceofexperimentalmanipulationalsorevealednormalPTandprolongedaPTT.Histologicexaminationsoftissuesfromallratswereunremarkableexceptforsevereacutefocallyextensivehemorrhagecorrespondingtothemacroscopicfindingsofacutehemorrhage.FurthermoretheaPTTin8clinicallynormaladultratsand8clinicallynormal4-wk-oldWAG/RijYlittermatesofbothsexeswasprolonged.WeconcludethattheseWAG/RijYratshaveaninheriteddefectintheintrinsiccoagulationpathway.

机译：HerewedescribeaseriesofcasesofspontaneouscoagulopathyinacolonyofinbredWAG / RijYcb（WAG / RijY）rats.Thisstrainpreviouslyhadbeenbredatourinstitutionwithoutsymptomatologyforseveraldecades.Theindexcasewasa10-WK-oldmaleratthatdevelopedalargehematomaatasubcutaneousinjectionsite.ClinicopathologicfindingsincludedadecreasedRBCcount，decreasedhematocrit，decreasedhemoglobinconcentration，normalPT，andprolonged（50％至70％）的aPTT（52S;参考，15to33s）.ExaminationofadditionalWAG / RijYratsthatdiedunexpectedlyorhadclinicalsignsofbleedingintheabsenceofexperimentalmanipulationalsorevealednormalPTandprolongedaPTT.Histologicexaminationsoftissuesfromallratswereunremarkableexceptforsevereacutefocallyextensivehemorrhagecorrespondingtothemacroscopicfindingsofacutehemorrhage.FurthermoretheaPTTin8clinicallynormaladultratsand8clinicallynormal4-延长了这两个星期的WAG / RijYlittermates的时间。我们认为这些WAG / RijYratshavean在固有凝血途径中继承了缺陷。

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《Comparative Medicine》 |2010年第1期|共页
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Booth Carmen J; Brooks Marjory B; Rockwell Sara;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats. [J] . Booth Carmen J., Brooks Marjory B., Rockwell Sara Comparative Medicine . 2010,第1期

机译：自交WAG / RijYcb大鼠的自发性凝固性疾病。
2. The Role of NMDA Receptors in the Effect of Purinergic P2X7 Receptor on Spontaneous Seizure Activity in WAG/Rij Rats With Genetic Absence Epilepsy [J] . Elif Do?an, Hatice Aygün, G?khan Arslan, Frontiers in Neuropharmacology . 2020,第a期

机译：NMDA受体在丙烯缺失癫痫术缺失癫痫中纯化P2X7受体对嘌呤能P2X7受体对自发癫痫发作活性作用的作用
3. Effect of Ceftriaxone on Spontaneous Epileptic Discharges in Genetic Absence Epileptic WAG/Rij Rats [J] . Tiryaki Emre Soner, Arslan Gokhan, Ayyildiz Mustafa, Acta physiologica . 2018,第S716期

机译：头孢曲松对遗传缺失癫痫发出癫痫发出癫痫发作的自发癫痫发出的影响
4. Laboratory Investigations Of First Contact Miscible Wag Displacement: The Effects Of Wag Ratio And Flow Rate [C] . H.S. Al-Shuraiqi, A.H.Muggeridge, C.A. Grattoni SPE international improved oil recovery conference in Asia Pacific (IIORC03) . 2003

机译：初次接触混溶蜡位移的实验室研究：摆动比和流速的影响
5. A spontaneous hereditary coagulopathy in Rambouillet sheep [D] . Johnson, Jeremy S. 2004

机译：朗布依埃绵羊的自发性遗传性凝血病
6. Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats [O] . Carmen J Booth, Marjory B Brooks, Sara Rockwell 2010

机译：自交WAG / RijYcb大鼠自发性凝血
7. Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats. [O] . D'Amore, V., Santolini, I., van Rijn, C.M., 2013

机译：用新型增强剂VU0360172增强mGlu5受体的活性可以减少WAG / Rij大鼠的自发性神志不清癫痫发作。
8. Preliminary geohydrologic site characterization and proposed water quality well locations for WAG 4, WAG 5, WAG 3, and SWSA 1 [R] . Baughn, D C 1987

机译：WaG 4，WaG 5，WaG 3和sWsa 1的初步地质水文站点特征描述和建议的水质井位置

Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats

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