Neuropathology of Bouncer Long Evans, a Novel Dysmyelinated Rat

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Neuropathology of Bouncer Long Evans, a Novel Dysmyelinated Rat

机译：新型的脱髓鞘大鼠Bouncer Long Evans的神经病理学

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Backgroundandpurpose:Spontaneousanimalmutantsaffectedbyabnormalformationofmyelininthecentralnervoussystem(CNS)areusefulinstudiesonmyelinogenesisandremyelinationleadingtobetterunderstandingofcellularandmolecularinteractionsinvolvedinmyelinrepair.Anovelratmutant,BouncerLongEvans(LE-bo)isseverelydysmyelinated,butwithexceptionallongevity,anditsclinicalandpathologicphenotypearedescribed.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Clinicalobservations,geneticstudies,anddeterminationoflongevitywereperformedinacolonyofrats,includingcarriersofLE-bophenotypeproducingthemutantanimals.Comprehensivehistologicstudieswereperformedonallperfusion-fixedtissues,andultrastructuralexaminationoftheopticnerveandthoracicpartofthespinalcordalsowasdoneinrats1to14weeksold.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:TheLE-bophenotypeischaracterizedbywholebodytremor,progressivelysevereataxia,andsevereseizureactivity.TheLE-bophenotypeistransferredasanautosomalrecessivetraitandisstable.TheLE-boratcansurviveingoodhealthbeyond45weeks.Neuropathologicchangesincludesevereglobaldysmyelination,withthinuncompactedmyelinsheathsinyoungratsformingnomajordenseline,whereasthemyelinsheathsoftheperipheralnervoussystemappearnormal.Oligodendrocytesdegeneratewithapparentlyprogressingaccumulationofmembranousmaterialintheperikaryon.LargenumbersofimmatureglialcellsweredetectedintheCNSofLE-boratsat4to14weeks.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:TheLE-boratisseverelydysmyelinatedduetoinabilityofitsoligodendrocytestoformmyelinsheaths.SimilaritiesoftheLE-boratandLongEvansShaker(les)ratneuropathologicfeatures,suchasseveredysmyelination,lackofmajordenselineinuncompactedmyelinsheaths,apparentproliferationofoligodendroglialcells,andconsiderablelongevity,arestrikingandsuggestthataLE-bomutationmayfunctionallyaffectthemyelinbasicproteingene.

机译：半边是我ndpurpose：Spontaneousanimalmutantsaffectedbyabnormalformationofmyelininthecentralnervoussystem（CNS）areusefulinstudiesonmyelinogenesisandremyelinationleadingtobetterunderstandingofcellularandmolecularinteractionsinvolvedinmyelinrepair.Anovelratmutant，BouncerLongEvans（LE-BO）isseverelydysmyelinated，butwithexceptionallongevity，anditsclinicalandpathologicphenotypearedescribed 方法：Clinicalobservations， geneticstudies，anddeterminationoflongevitywereperformedinacolonyofrats，簇集成振动贝里ersofLE-bophenotypeproducingthemutantanimals.Comprehensivehistologicstudieswereperformedonallperfusion-fixedtissues，andultrastructuralexaminationoftheopticnerveandthoracicpartofthespinalcordalsowasdoneinrats1to14weeksold 结果：R-bophenotypeischaracterizedbywholebodytremor，亲GRE委员会产生NYSE产生一个重新共济失调，andsevereseizureactivity.TheLE-表现型转移为常染色体隐性遗传我rasstavanie ble.TheLE-boratcansurviveingoodhealthbeyond45weeks.Neuropathologicchangesincludesevereglobaldysmyelination，命令和NU推荐路口ICT浓度为贪Bhangrapunjabi SFO蛭石马格诺可能条目寻找阿伯丁nseline，轴距记录被拒绝很可能Fudgy在PE里PHE RA巴尔内阿里奥坎伺服ssyste流体阿诺缅甸l.O暴力，直到Android的莱特DrossRotzank当局RA TE无线采取阿帕杜莱重新ntlypro温室委员会不累计有一个FME胸罩和SMA征用已平均PE里n.La乔治NU可靠个人接入被告人涂重新阿布鲁不Dolceacqua的llswe重新德特ICT集成ntheCNSofLE-boratsat4to14weeks 预告：R-boratisseverelydysmyelinatedduetoinabilityofitsoligodendrocytestoformmyelinsheaths.SimilaritiesoftheLE- boratandLongEvansShaker（les）大鼠的神经病理学特征，如髓鞘变性，未压实的髓鞘缺乏主要的密集线，少突胶质细胞的明显增殖以及相当长的寿命，在其中存在着明显的突变。

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《Comparative Medicine》 |2000年第5期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Structural and functional alterations of spinal cord axons in adult Long Evans Shaker (LES) dysmyelinated rats. [J] . Eftekharpour E, Karimi Abdolrezaee S, Sinha K, Experimental Neurology . 2005,第2期

机译：成年长Evans摇床（LES）脱髓鞘的大鼠脊髓轴突的结构和功能改变。
2. Ventilatory impairment in the dysmyelinated Long Evans shaker rat. [J] . Johnson RA, Baker Herman TL, Duncan ID, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2010,第3期

机译：呼吸困难长埃文斯摇椅大鼠呼吸困难的通风障碍。
3. Characterization of the optic nerve and retinal ganglion cell layer in the dysmyelinated adult Long Evans Shaker rat: evidence for axonal sprouting. [J] . Phokeo V, Kwiecien JM, Ball AK The Journal of Comparative Neurology . 2002,第3期

机译：发育不良的成年长埃文斯摇床大鼠的视神经和视网膜神经节细胞层的表征：轴突发芽的证据。
4. Neuropathology In Rats Exposed To Pulsed And Continuous-wave RF Radiation: A Preliminary Study [C] . Campbell C.B.G., Hunt E.L., Bates F., Engineering in Medicine and Biology Society, 1991. Vol.13: 1991., Proceedings of the Annual International Conference of the IEEE . 1991

机译：暴露于脉冲和连续波RF辐射的大鼠的神经病理学：初步研究
5. The Experienced Palate is a Smart Palate - A Behavioral and Neural Investigation of the Impact of Incidental Taste Experience on Future Taste Learning in Female Long Evans Rats [D] . Flores, Veronica Lee. 2019

机译：经验丰富的味觉是聪明的味觉-行为和神经调查，偶然的味觉体验对雌性长Evans大鼠未来味觉学习的影响
6. Ventilatory impairment in the dysmyelinated Long Evans shaker (les) rat [O] . Rebecca A. Johnson, Tracy L. Baker-Herman, Ian D. Duncan, -1

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7. The role of small proliferative adipocytes in the development of obesity: Comparison between Otsuka Long-Evans Tokushima Fatty (OLETF) rats and non-obese Long-Evans Tokushima Otsuka (LETO) rats [O] . Takayuki Hanamoto, Kazuo Kajita, Ichiro Mori, 2013

机译：小型增殖性脂肪细胞在肥胖发展中的作用：otosuka长evans tokushima脂肪（Oletf）大鼠和非肥胖长埃文斯Tokushima大冢（Leto）大鼠的比较
8. Reservoir Engineering and Treatment Design Technology. Topical Well ReportComprehensive Study Wells 4 and 4A (CSW's 4 and 4A), Ashland Exploration Inc., E.J. Evans No. 89 (CSW 4) and E.J. Evans No. 91 (CSW 4A), Breathitt County, KY. Topical Report, April [R] . Murtha, J. A., Lancaster, D. E. 1992

机译：油藏工程与处理设计技术。专题报告综合研究井4和4a（CsW 4和4a），ashland Exploration Inc.，E.J。埃文斯第89号（CsW 4）和E.J. Evans No. 91（CsW 4a），肯塔基州布雷希特县。专题报告，4月

Neuropathology of Bouncer Long Evans, a Novel Dysmyelinated Rat

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