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Outbreak of Orthoreovirus-Induced Meningoencephalomyelitis in Baboons

机译：狒狒中正咽病毒引起的脑膜脑脊髓炎的暴发

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BackgroundandPurpose:Spontaneousviralencephalitisisrareinthebaboon;yet,duringa13-monthperiod(1993#8211;1994),eightjuvenilebaboons(Papiocynocephalusspp.)developedacute,progressivenonsuppurativemeningoencephalomyelitiscausedbyanunknownagent.Clinicalsignsofdiseaseincludeddisorientationandtruncalataxiathatrapidlyprogressedtohemiparesisorparaparesis.Clinicopathologicfindingswerenotremarkableandappreciablegrosslesionswerenotseenatnecropsy.MicroscopicexaminationrevealedCNSlesionsthatwerecharacterizedbylymphoplasmacyticperivascularcuffing,microglialnodules,demyelination,axonaldegeneration,vacuolization,andhemorrhage.Subsequently,anovelsyncytium-inducingmammalianorthoreoviruswasisolatedfromthebraintissueoffivebaboonswithclinicalsignsofinfection.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Toconfirmtheetiologicroleoftheorthoreovirus,twojuvenilebaboonswereinoculatedwiththevirus,thenweremonitoredfor6weeks.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:LesionssimilartothoseseeninspontaneouscaseswerefoundintheCNS,andorthoreoviruswasisolatedfromthebrainofbothanimals.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:Analysisoftheoutbreakindicatedjuvenilebaboonsweremostsusceptibletodiseaseandthevirushadapossibleincubationtimeof46to66days,butdidnotindicateasourceofthevirusormodeoftransmission.
机译：BackgroundandPurpose：Spontaneousviralencephalitisisrareinthebaboon;然而，duringa13-monthperiod（1993＃8211; 1994），eightjuvenilebaboons（Papiocynocephalusspp）developedacute，progressivenonsuppurativemeningoencephalomyelitiscausedbyanunknownagent.Clinicalsignsofdiseaseincludeddisorientationandtruncalataxiathatrapidlyprogressedtohemiparesisorparaparesis.Clinicopathologicfindingswerenotremarkableandappreciablegrosslesionswerenotseenatnecropsy.MicroscopicexaminationrevealedCNSlesionsthatwerecharacterizedbylymphoplasmacyticperivascularcuffing，microglialnodules，脱髓鞘，axonaldegeneration，空泡化，andhemorrhage.Subsequently，anovelsyncytium-inducingmammalianorthoreoviruswasisolatedfromthebraintissueoffivebaboonswithclinicalsignsofinfection / 方法：要确认甲状疱疹病毒的病因学原理，将两个幼年狒狒接种该病毒，并监控6周。 结果：会议 结论：对绝大部分病毒病的研究表明，该病态的绝大部分原因是有可能的，但在此之前，有46种病态的病态细菌被认为是可疑的。

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