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Acetonitrile-Induced Destabilization in Liposomes

机译:乙腈引起的脂质体不稳定

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To understand the behavior of cellular interfaces, it is important to clarify the effect of chemical compounds on artificial cell membranes. In this study, an aqueous acetonitrile solution was mixed with a suspension of lipid vesicles, and the changes in vesicle behavior arising as a result of acetonitrile application were observed. The fast Fourier transformations (FFTs) of the membrane waviness/crinkliness of the vesicles were carried out, and the membrane thermal fluctuations were analyzed. The experimental results show that the addition of acetonitrile molecules enhances the fluctuation of lipid membranes. In particular, the k = 2 mode fluctuation was significantly enhanced. This finding is expected to lead us to a further understanding of the fundamental properties of living cells.
机译:要了解细胞界面的行为,弄清化合物对人造细胞膜的作用非常重要。在这项研究中,将乙腈水溶液与脂质囊泡的悬浮液混合,并观察到由于使用乙腈而引起的囊泡行为的变化。进行囊泡膜起伏/起皱的快速傅立叶变换(FFT),并分析膜的热涨落。实验结果表明,添加乙腈分子可增加脂质膜的波动。特别是,k = 2模式的波动显着增强。该发现有望使我们对活细胞的基本特性有进一步的了解。

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