The Laboratory Rat as an Animal Model for Osteoporosis Research

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The Laboratory Rat as an Animal Model for Osteoporosis Research

机译：实验性大鼠作为骨质疏松症研究的动物模型

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Osteoporosisisanimportantsystemicdisorder,affectingmainlyCaucasianwomen,withadiverseandmultifactorialetiology.Alargevarietyofanimalspecies,includingrodents,rabbits,dogs,andprimates,havebeenusedasanimalmodelsinosteoporosisresearch.Amongthese,thelaboratoryratisthepreferredanimalformostresearchers.Itsskeletonhasbeenstudiedextensively,andalthoughthereareseverallimitationstoitssimilaritytothehumancondition,thesecanbeovercomethroughdetailedknowledgeofitsspecifictraitsorwithcertaintechniques.Therathasbeenusedinmanyexperimentalprotocolsleadingtoboneloss,includinghormonalinterventions(ovariectomy,orchidectomy,hypophysectomy,parathyroidectomy),immobilization,anddietarymanipulations.Theaimofthecurrentreviewisnotonlytopresenttheovariectomizedratanditsadvantagesasanappropriatemodelfortheresearchofosteoporosis,butalsotoprovideinformationaboutthemostrelevantageandbonesiteselectionaccordingtothegoalsofeachexperimentalprotocol.Inaddition,severalmethodsofbonemassevaluationareassessed,suchasbiochemicalmarkers,densitometry,histomorphometry,andbonemechanicaltesting,thatareusedformonitoringandevaluationofthisanimalmodelinpreventiveortherapeuticstrategiesforosteoporosis.

机译：Osteoporosisisanimportantsystemicdisorder，affectingmainlyCaucasianwomen，withadiverseandmultifactorialetiology.Alargevarietyofanimalspecies，includingrodents，兔，狗，andprimates，havebeenusedasanimalmodelsinosteoporosisresearch.Amongthese，thelaboratoryratisthepreferredanimalformostresearchers.Itsskeletonhasbeenstudiedextensively，andalthoughthereareseverallimitationstoitssimilaritytothehumancondition，thesecanbeovercomethroughdetailedknowledgeofitsspecifictraitsorwithcertaintechniques.Therathasbeenusedinmanyexperimentalprotocolsleadingtoboneloss，includinghormonalinterventions（卵巢，睾丸，垂体，甲状旁腺切除术），固定化，anddietarymanipulations.Theaimofthecurrentreviewisnotonlytopresenttheovariectomizedratanditsadvantagesasanappropriatemodelfortheresearchofosteoporosis，butalsotoprovideinformationaboutthemostrelevantageandbonesiteselectionaccordingtothegoalsofeachexperimentalprotocol.Inaddition ，评估了几种评价方法，例如生化法rkers，密度测定法，组织形态测定法和骨力学测试，用于预防和治疗骨质疏松症的动物模型的监测和评估。

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《Comparative Medicine》 |2008年第5期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. The laboratory rat as an animal model for osteoporosis research [J] . Lelovas PP, Xanthos TT, Thoma SE, Comparative Medicine . 2008,第5期

机译：实验大鼠作为骨质疏松症研究的动物模型
2. FELASA recommendations for the accreditation of laboratory animal science education and training - Report of the Federation of European Laboratory Animal Science Associations Working Group on Accreditation of Laboratory Animal Science Education and T [J] . Nevalainen T, Blom HJM, Guaitani A, Laboratory Animals . 2002,第4期

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3. Roles of the International Council for Laboratory Animal Science (ICLAS) and International Association of Colleges of Laboratory Animal Medicine (IACLAM) in the Global Organization and Support of 3Rs Advances in Laboratory Animal Science [J] . Turner Patricia V., Pekow Cynthia, Clark Judy MacArthur, Journal of the American Association for Laboratory Animal Science . 2015,第2期

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4. The effects of honey (Apis dorsata) supplements on increased bone strength in ovariectomized rat as animal model of osteoporosis [C] . Ira Sari Yudaniayanti, Hardany Primarizky, Lianny Nangoi International Conference on Materials and Metallurgical Engineering and Technology . 2018

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5. Model for suspended gate field effect transistors used in laboratory animal cage monitoring. [D] . Supan, Karen E. 2005

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6. The Laboratory Rat as an Animal Model for Osteoporosis Research [O] . Pavlos P Lelovas, Theodoros T Xanthos, Sofia E Thoma, 2008

机译：作为骨质疏松症研究动物模型的实验大鼠
7. Guidelines for the care of laboratory animals in transit: Laboratory animal breeders association of great britain limited (LABA) and Laboratory animal science association (LASA) [O] . 1993

机译：在途过境的实验室动物护理指南：大不列颠及利社（Laba）和实验室动物科学协会（LASA）的实验动物育种者协会

The Laboratory Rat as an Animal Model for Osteoporosis Research

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