Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice

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Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice

机译：AntiPax5在小鼠淋巴增生性疾病和瘤形成的诊断中的效用

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CD45R/B220antigen(B220)isacommonmousepanB-cellmarkerusedforparaffin-embeddedtissues.However,antiB220haslimitedspecificityindiagnosticpathologybecausetheB220antigenisexpressedonsubsetsofcytotoxicTlymphocytesandnaturalkillercells,onplasmacyticdendriticcells,andonTlymphocytesofmicewiththelymphoproliferativedisorderassociatedwithFas(lymphoproliferativemutantmouse,B6.MRL-Fassuplpr/sup/J)orFasligand(generalizedlymphoproliferativediseasemutantmouse,C3H/HeJ-Faslsupgld/sup/JorB6Smn.C3-Faslsupgld/sup/J).Inaddition,mouseBlymphocytesvaryintheamountofB220expressed,andsomesubsetsofmouseBlymphocytesdonotexpressB220atall.Incomparison,Pax5expression(detectedbyimmunohistochemistryusingantiPax5)offersgreaterspecificityandsensitivitybecauseofitsearlierexpressionduringB-celldifferentiation,itsabilitytodetectallcommittedBcells,anditsrestrictiontotheB-celllineage.HerewedescribetheuseofanantibodytohumanPax5indiagnosticpathologywithformalin-fixed,paraffin-embeddedmousetissue.

机译：CD45R / B220antigen（B220）isacommonmousepanB-cellmarkerusedforparaffin-embeddedtissues.However，antiB220haslimitedspecificityindiagnosticpathologybecausetheB220antigenisexpressedonsubsetsofcytotoxicTlymphocytesandnaturalkillercells，onplasmacyticdendriticcells，andonTlymphocytesofmicewiththelymphoproliferativedisorderassociatedwithFas（lymphoproliferativemutantmouse，B6.MRL-FAS ^{LPR / J）orFasligand（generalizedlymphoproliferativediseasemutantmouse，C3H / HeJ小鼠-FASL ^{GLD /JorB6Smn.C3-Fasl ^{GLD / J）.Inaddition，mouseBlymphocytesvaryintheamountofB220expressed，andsomesubsetsofmouseBlymphocytesdonotexpressB220atall.Incomparison，Pax5expression（detectedbyimmunohistochemistryusingantiPax5）offersgreaterspecificityandsensitivitybecauseofitsearlierexpressionduringB-细胞分化，itsabilitytodetectallcommittedBcells，anditsrestrictiontotheB-celllineage.HerewedescribetheuseofanantibodytohumanPax5indiagnosticpathologywithformalin固定，石蜡包埋的粘膜组织。}}}

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《Comparative Medicine》 |2008年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice. [J] . Rehg J.E., Sundberg J.P. Comparative Medicine . 2008,第3期

机译：AntiPax5在小鼠淋巴增生性疾病和瘤形成的诊断中的效用。
2. The Utility of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration Biopsy in the Diagnosis of Mediastinal Lymphoproliferative Disorders [J] . Carrie B. Marshall, Betsy Jacob, Shobhana Patel, Cancer: A Journal of the American Cancer Society . 2011,第2期

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6. Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice [O] . Jerold E Rehg, John P Sundberg 2008

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Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice

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