Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice

Chichlowski Maciej; Sharp Julie M; Vanderford Deborah A; Myles Matthew H; Hale Laura P

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Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice

机译：Typhlonius幽门螺杆菌和啮齿类幽门螺杆菌差异影响IL10缺陷小鼠结肠炎症和炎症相关肿瘤的严重程度

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InfectionwithHelicobacterspeciesisendemicinmanyanimalfacilitiesandmayalterthepenetranceofinflammatoryboweldisease(IBD)phenotypes.However,littleisknownabouttherelativepathogenicityofH.typhlonius,H.rodentium,andcombinedinfectioninIBDmodels.WeinfectedadultandneonatalIL10supxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/#8211;/supmicewithH.typhlonius,H.rodentium,orbothbacteria.TheseverityofIBDandincidenceofinflammation-associatedcolonicneoplasiawereassessedinthepresenceandabsenceofantiHelicobactertherapy.InfectedIL10supxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/#8211;/supmicedevelopedIBDwithseverityofnoninfected(minimaltonoinflammation)H.rodentiumH.typhloniusmixedH.rodentium+H.typhlonius(severeinflammation).Inflammation-associatedcolonicneoplasiawascommonininfectedmiceanditsincidencecorrelatedwithIBDseverity.Combinedtreatmentwithamoxicillin,clarithromycin,metronidazole,andomeprazoleeradicatedHelicobacterininfectedmiceandamelioratedestablishedIBDinbothinfectedandnoninfectedmice.InfectionofIL10supxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/#8211;/supmicewithH.rodentium,H.typhlonius,orbothorganismscantriggerdevelopmentofsevereIBDthateventuallyleadstocolonicneoplasia.Thehighincidenceandmultiplicityofneoplasticlesionsininfectedmicemakethismodelwell-suitedforfutureresearchrelatedtothedevelopmentandchemopreventionofinflammation-associatedcoloncancer.ThesimilarantiinflammatoryeffectofantibiotictherapyinHelicobacter-infectedand-noninfectedIL10supxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/#8211;/supmicewithcolitisindicatesthatunidentifiedmicrobiotainadditiontoHelicobacterdrivetheinflammatoryprocessinthismodel.ThisfindingsuggestsacomplexroleforbothHelicobacterandotherintestinalmicrobiotaintheonsetandperpetuationofIBDinthesesusceptiblehosts.

机译：幽门螺杆菌，H.rodentium和结合感染在IBD模型中的相关病原性尚不多。 IBD的严重性和炎症相关的结肠神经病的发生率通过评估是否存在抗幽门螺杆菌疗法而被感染。＃8211; /＃8211; micewithH.rodentium，H.typhlonius，orbothorganismscantriggerdevelopmentofsevereIBDthateventuallyleadstocolonicneoplasia.Thehighincidenceandmultiplicityofneoplasticlesionsininfectedmicemakethismodelwell-suitedforfutureresearchrelatedtothedevelopmentandchemopreventionofinflammation-associatedcoloncancer。幽门螺杆菌感染的细菌在未感染的IL10中具有相似的抗炎作用＃8211; /＃8211; 小鼠结肠炎表明，在此模型中，此细菌在宿主体内的微生物菌丝和细菌在此细菌中的存在是由微生物和细菌共同作用的。

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《Comparative Medicine》 |2008年第6期|共页
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Chichlowski Maciej; Sharp Julie M; Vanderford Deborah A; Myles Matthew H; Hale Laura P;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice [J] . Chichlowski Maciej, Sharp Julie M., Vanderford Deborah A., Comparative Medicine . 2008,第6期

机译：Typhlonius幽门螺杆菌和啮齿类幽门螺杆菌差异影响IL10缺陷小鼠结肠炎症和炎症相关肿瘤的严重程度
2. Neonatal co-infection with Helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-)mice [J] . Hale LP, Perera D, Gottfried MR, Helicobacter . 2007,第6期

机译：新生儿与幽门螺杆菌的共感染显着加速了IL-10（-/-）小鼠中与炎症相关的结肠肿瘤的发展
3. Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice [J] . Talero Elena, Alcaide Antonio, Avila-Roman Javier, International immunopharmacology . 2016,第Null期

机译：sirtuin 1-AMPK自噬途径在IL-10缺陷小鼠慢性结肠炎和炎症相关结肠肿瘤中的表达模式
4. Quantification of inflammation-induced oxidized deoxyguanosine lesion in colon and liver from Helicobacter hepaticus-infected Rag2-deficient mice [C] . Wenjie Ye, Aswin Mangerich, Liang Cui, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：炎症诱导的氧化脱氧胍病病变的结肠杆菌感染肝病感染的RAG2缺陷小鼠
5. Lipid-Soluble Compounds in Late-Cutting Alfalfa Maximize Host Immune Responses and Beneficially Modulate the Colon Microbiota of Mice during Citrobacter rodentium Infection [D] . Craft, Krysten A. 2019

机译：晚切割的脂质可溶性化合物最大化宿主免疫应答，并在柠檬杆菌感染期间有利地调节小鼠的结肠微生物群
6. Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice [O] . Maciej Chichlowski, Julie M Sharp, Deborah A Vanderford, 2008

机译：Typhlonius幽门螺杆菌和啮齿类幽门螺杆菌差异影响IL10缺陷小鼠结肠炎症和炎症相关肿瘤的严重程度
7. Helicobacter rodentium sp. nov., a Urease-Negative Helicobacter Species Isolated from Laboratory Mice [O] . Z. Shen, J. G. Fox, F. E. Dewhirst, 1997

机译：鼠李杆菌sp。 11月。，一种从实验室小鼠分离的脲酶阴性幽门杆菌

Helicobacter typhlonius and Helicobacter rodentium Differentially Affect the Severity of Colon Inflammation and Inflammation-Associated Neoplasia in IL10-Deficient Mice

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