Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus

Alvarado Cynthia G; Kocsis Andrew G; Hart Marcia L; Crim Marcus J; Myles Matthew H; Franklin Craig L

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Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus

机译：ganmani Helicobacter ganmani在易感且抗肝H.感染的小鼠中的致病性

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Helicobacterspp.aresomeofthemostprevalentbacterialcontaminantsoflaboratorymice.AlthoughabundantdataregardingthediseasesassociatedwithH.hepaticusinfectionareavailable,littleisknownaboutthepathogenicityofH.ganmani,whichwasfirstisolatedin2001fromtheintestinesoflaboratorymice.TheobjectiveofthisstudywastoevaluatethehostresponsetoH.ganmanicolonizationinH.hepaticusdisease-resistantC57BL/6anddisease-susceptibleA/JandIL10-deficientmice.MicewereinoculatedwithH.ganmani,H.hepaticus,orBrucellabroth.Cecallesionscores,cecalgeneexpression,andHelicobacterloadweremeasuredat4and90dafterinoculation.Atbothtimepoints,miceinoculatedwithH.ganmanihadsimilarorsignificantlymorecopiesofcecum-associatedHelicobacterDNAthandidmiceinoculatedwithH.hepaticus.Whencomparedwiththoseofsham-inoculatedcontrolmice,cecallesionscoresat4and90dafterinoculationwerenotsignificantlygreaterinH.ganmani-inoculatedA/J,C57BL/6,orIL10-deficientmice.AnalysisofcecalgeneexpressiondemonstratedthatH.ganmaniinfectionfailedtocausesignificantelevationsofIFN#947;inA/J,C57BL/6,orIL10-deficientmice.However,inIL10-deficientmice,H.ganmaniinfectionwasassociatedwithasignificantincreaseintheexpressionoftheproinflammatorycytokineIL12/23p40.AlthoughH.ganmaniinfectioninthisstudyfailedtoinducethetyphlitisthatisthehallmarkofH.hepaticusinfection,infectionwithH.ganmaniwasassociatedwithalterationsininflammatorycytokinesinIL10-deficientmice.

机译：Helicobacterspp.aresomeofthemostprevalentbacterialcontaminantsoflaboratorymice.AlthoughabundantdataregardingthediseasesassociatedwithH.hepaticusinfectionareavailable，littleisknownaboutthepathogenicityofH.ganmani，whichwasfirstisolatedin2001fromtheintestinesoflaboratorymice.TheobjectiveofthisstudywastoevaluatethehostresponsetoH.ganmanicolonizationinH.hepaticusdisease-resistantC57BL / 6anddisease-susceptibleA / JandIL10-deficientmice.MicewereinoculatedwithH.ganmani，H.hepaticus，orBrucellabroth.Cecallesionscores，cecalgeneexpression，andHelicobacterloadweremeasuredat4and90dafterinoculation.Atbothtimepoints，miceinoculatedwithH。 ganmani与假接种的对照小鼠相比，与盲肠相关的幽门螺杆菌DNA拷贝数更多或更多。与假接种的对照小鼠相比，在接种后的大肠菌群中C的表达没有显着性差异，表明甘菊糖在Ca上被充分分析的C的甘尼马氏菌在C上显示出足够的特异性，这表明甘马尼氏菌在C上被充分分析的原因是在10个月以后，Camanici可能被认为是足够的。在A / J，C57BL / 6或IL10缺乏的小鼠中，IFN＃947的表达。然而，在IL10缺乏的小鼠中，H.ganmani感染与促炎性细胞因子IL12 / 23p40的表达显着增加有关，尽管这与研究中的H.ganmani感染无关，但仍提示这种情况。

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《Comparative Medicine》 |2015年第1期|共页
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Alvarado Cynthia G; Kocsis Andrew G; Hart Marcia L; Crim Marcus J; Myles Matthew H; Franklin Craig L;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus [J] . Alvarado Cynthia G., Kocsis Andrew G., Hart Marcia L., Comparative Medicine . 2015,第1期

机译：ganmani Helicobacter ganmani在易感且抗肝杆菌感染的小鼠中的致病性
2. Monitoring Sentinel Mice for Helicobacter hepaticus, H. rodentium, and H. bilis Infection by Use of Polymerase Chain Reaction Analysis and Serologic Testing [J] . Comparative Medicine . 2000,第4期

机译：通过聚合酶链反应分析和血清学检测监测前哨鼠肝炎，啮齿类杆菌和胆汁感染
3. Helicobacter bilis Infection Accelerates and H. hepaticus Infection Delays the Development of Colitis in Multiple Drug Resistance-Deficient (mdr1a-/-) Mice [J] . Lillian Maggio-Price, Donna Shows, Kim Waggie, American Journal of Pathology . 2002,第2期

机译：Helicobacter bilis感染会加速，H。hepaticus感染会延迟多药耐药性（mdr1a-/-）小鼠结肠炎的发展
4. Quantification of inflammation-induced oxidized deoxyguanosine lesion in colon and liver from Helicobacter hepaticus-infected Rag2-deficient mice [C] . Wenjie Ye, Aswin Mangerich, Liang Cui, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：炎症诱导的氧化脱氧胍病病变的结肠杆菌感染肝病感染的RAG2缺陷小鼠
5. Comparative analysis of Yersinia pestis infection in resistant and susceptible mice [D] . Lambert, Nathaniel D. 2011

机译：耐药和易感小鼠鼠疫耶尔森菌感染的比较分析
6. Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus [O] . Cynthia G Alvarado, Andrew G Kocsis, Marcia L Hart, 2015

机译：ganmani Helicobacter ganmani在易感且抗肝H.感染的小鼠中的致病性
7. Dual Infection with Helicobacter bilis and Helicobacter hepaticus in P-Glycoprotein-Deficient mdr1a−/− Mice Results in Colitis that Progresses to Dysplasia [O] . Lillian Maggio-Price, Helle Bielefeldt-Ohmann, Piper Treuting, 2005

机译：双嗜糖蛋白缺乏MDR1A - / - 小鼠患有幽门螺杆菌和肝动杆菌的双重感染导致结肠炎进入发育不良

Pathogenicity of Helicobacter ganmani in Mice Susceptible and Resistant to Infection with H. hepaticus

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