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首页> 外文期刊>Comparative and functional genomics >Gene Expression Profiling of Grass Carp (Ctenopharyngodon idellus) and Crisp Grass Carp
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Gene Expression Profiling of Grass Carp (Ctenopharyngodon idellus) and Crisp Grass Carp

机译：草鱼（Ctenopharyngodon idellus）和脆草鱼的基因表达谱

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Grass carp (Ctenopharyngodon idellus) is one of the most important freshwater fish that is native to China, and crisp grass carp is a kind of high value-added fishes which have higher muscle firmness. To investigate biological functions and possible signal transduction pathways that address muscle firmness increase of crisp grass carp, microarray analysis of 14,900 transcripts was performed. Compared with grass carp, 127 genes were upregulated and 114 genes were downregulated in crisp grass carp. Gene ontology (GO) analysis revealed 30 GOs of differentially expressed genes in crisp grass carp. And strong correlation with muscle firmness increase of crisp grass carp was found for these genes from differentiation of muscle fibers and deposition of ECM, and also glycolysis/gluconeogenesis pathway and calcium metabolism may contribute to muscle firmness increase. In addition, a number of genes with unknown functions may be related to muscle firmness, and these genes are still further explored. Overall, these results had been demonstrated to play important roles in clarifying the molecular mechanism of muscle firmness increase in crisp grass carp.
机译：草鱼（Ctenopharyngodon idellus）是中国最重要的淡水鱼之一，脆草鱼是一种高附加值的鱼，具有较高的肌肉硬度。为了研究解决脆皮草鱼肌肉硬度增加的生物学功能和可能的信号转导途径，对14,900个转录本进行了微阵列分析。与草鱼相比，脆草鱼的127个基因被上调，而114个基因被下调。基因本体论（GO）分析揭示了脆草鱼中30个GOs差异表达基因。这些基因通过肌纤维的分化和ECM的沉积而与脆皮草鱼的肌肉硬度增加紧密相关，糖酵解/糖异生途径和钙代谢也可能有助于肌肉硬度的增加。另外，许多功能未知的基因可能与肌肉硬度有关，这些基因仍在进一步探索中。总体而言，这些结果已被证明在阐明脆皮草鱼肌肉硬度增加的分子机制中起重要作用。

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