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首页> 外文期刊>Comparative Medicine >Retrospective Evaluation of Cardiopulmonary and Acid-Base Variables During Long-Term Balanced Anesthesia for Experimental Surgery in Dogs
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Retrospective Evaluation of Cardiopulmonary and Acid-Base Variables During Long-Term Balanced Anesthesia for Experimental Surgery in Dogs

机译：犬长期平衡麻醉实验手术中心肺和酸碱变量的回顾性评估

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Cardiopulmonaryandacid-basevariablesrecordedduringlong-termbalancedanesthesialastingbetween12.5and16.9hwereevaluatedretrospectivelyin15healthyfoxhoundsthatunderwentexperimentalbullaosteotomywithimplantationofhearingaids.Afterpremedicationwithpropionylpromazine(0.110.02mg/kgofbodyweight)andL-methadone(0.710.06mg/kg)intravenously(i.v.)andinductionwithpentobarbitalsodium(6.020.83mg/kgi.v.),anesthesiawasmaintainedwithhalothane(end-tidalconcentration;ETsubxmlns="http://pub2web.metastore.ingenta.coms/"HAL/sub:0.4to1.5%)innitrousoxide(2L/min)andoxygen(1L/min).Becauseofpositionalchangesfromsternaltorightlateralrecumbencyafterpresurgicalbrainstemelectricresponseaudiometryanddifferencesindurationofsurgery,dataobtainedbetween4(baseline)and14hafterinductionofanesthesiawereanalyzed.Arterial(Paosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub)andalveolar(PAosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub)Osubxmlns="http://pub2web.metastore.ingenta.coms/"2/subtensions,arterial-to-alveolarO2tensionratio(Paosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub/PAosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub),andarterialOsubxmlns="http://pub2web.metastore.ingenta.coms/"2/subcontent(Caosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub)remainedrelativelystablethroughoutanesthesia.Arterialcarbondioxidetension(Pacosubxmlns="http://pub2web.metastore.ingenta.coms/"2/sub)wassignificantlyincreasedabovebaseline(39,33to46mmHg[median,range])between7(39.8,36.5to48.9mmHg)and9(42,37.5to49.5mmHg)hafterinduction.BecausechangesinPacosubxmlns="http://pub2web.metastore.ingenta.coms/"2/subwereaccompaniedbysignificantincreasesinbodytemperaturefrombaseline(36.3,34.6to37.4°C)between8(37.1,35to38°C)and11(37.6,35.3to38.1°C)hafteranesthesiainductionaswellasbyslightincreasesinarterialbloodpressure,thePacosubxmlns="http://pub2web.metastore.ingenta.coms/"2/subincreasemayhavebeencausedbyincreaseinmetabolicCOsubxmlns="http://pub2web.metastore.ingenta.coms/"2/subproductionandenhanceddrainageofCOsubxmlns="http://pub2web.metastore.ingenta.coms/"2/subfromthetissuesintosystemiccirculation.Furthermore,mildmetabolicacidosis(pHa:7.31,7.26to7.38;HCOsubxmlns="http://pub2web.metastore.ingenta.coms/"3/subsupxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/sup:18.9,16.7to21.8mEq/L;basedeficit[BD]:-6.3,-8.5to-3.4mEq/L)alreadyexistedat4hafterinductionandwasrelatedinparttotissuehypoperfusion.SmallincreasesinpHaduringthecourseofanesthesiawereaccompaniedbysignificantincreasesinHCOsubxmlns="http://pub2web.metastore.ingenta.coms/"3/subsupxmlns="http://pub2web.metastore.ingenta.coms/"#8211;/supconcentrationandsignificantdecreasesinBDbetween5and10hafterinduction.Minorcircumscribedswellingofthedependenttricepsormassetermusclewasnoticedonthefirstpostoperativedayintwodogs,andmarkedtissueswellingwithhematomaformationatthemedialsideofonehindlimbwasnoticedinathirddog.Alldogsrecoveredcompletelyandweresubmittedtofollow-upstudies.Theanestheticprotocolandextentofmonitoringusedwereadequatetoprovidesafelong-termanesthesiaforanexperimentalsurgicalprocedurewitha100%survivalrateanduneventfulrecoveryinmostofthedogs.
机译：Cardiopulmonaryandacid-basevariablesrecordedduringlong-termbalancedanesthesialastingbetween12.5and16.9hwereevaluatedretrospectivelyin15healthyfoxhoundsthatunderwentexperimentalbullaosteotomywithimplantationofhearingaids.Afterpremedicationwithpropionylpromazine（0.110.02mg / kgofbodyweight）和L-美沙酮（0.710.06mg /千克）静脉内（IV）andinductionwithpentobarbitalsodium（6.020.83mg / kgi.v。），anesthesiawasmaintainedwithhalothane（端tidalconcentration; ET HAL ：亚硝基氧化物（2L / min）和氧气（1L / min）中的0.4至1.5％。由于在术前脑电反应性听力测验后，从内部到右侧的横卧位变化，测得的数据和差值（4）动脉麻醉（Pao 2 ）和动脉（PAo 2 ）O 2 tens离子，动脉到肺的O2张力比（Pao 2 / PAo 2 ）和arterialO 2 content（Cao 2 ）保持相对稳定。动脉血二氧化碳浓度（Paco 2 ）显着高于基线水平感应后的7（39.8,36.5至48.9mmHg）和9（42,37.5至49.5mmHg）之间的（39,33至46mmHg [中位数，范围]）。因为Paco 2 伴随着体温从8（37.1,35to38°C）和11（37.6,35.3至38.1°C）之间的基线温度（36.3,34.6至37.4°C）显着升高，同时由于动脉血压的轻微升高而升高，Pacopub 2 的增加可能是由于inmetabolicCO 2 productionandenhanceddrainageofCO 2 从组织中转移到系统循环中。 ，mildmetabolicacidosis（pHa：7.31,7.26to7.38; HCO 3 #8211;：18.9,16.7至21.8mEq / L;基于效率[BD]：-6.3，-8.5至3.4mEq / L）在诱导后4小时内就已经存在，并且在组织低渗中与XML有关。 ：//pub2web.metastore.ingenta.coms/“> 3 ＃8211; 浓度和显着降低后BD到10h。并在第三只狗的后肢内侧出现带有血肿形成的明显组织的血液，这是第三只狗被发现的原因。麻醉后的监测范围足以为实验性手术提供安全的长期麻醉，手术率高达100％，并且大多数犬无法恢复。

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