Pathologic Findings in Rabbit Models of Hereditary Hypertriglyceridemia and Hereditary Postprandial Hypertriglyceridemia

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Pathologic Findings in Rabbit Models of Hereditary Hypertriglyceridemia and Hereditary Postprandial Hypertriglyceridemia

机译：遗传性高甘油三酸酯血症和遗传性餐后高甘油三酯血症兔模型的病理发现

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Inrecentyears,theassociationbetweenhyperlipidemiaandthedevelopmentofarteriosclerosishasbeenaddressedinseveralstudies.Rabbitmodelsofhypertriglyceridemia(TGH)andpostprandialhypertriglyceridemia(PHT)havebeendevelopedattheauthors'institute.TGHrabbitsmanifestpathologysimilartothatofhumanswithTGH,suchasxanthoma,inadditiontoatherosclerosisofarterioles.Furthermore,PHTrabbitsshowvisceralobesity,insulinresistance,andimpairedglucosetolerance,withpathologicfeaturessimilartothoseofthemetabolicsyndromeassumedtobethecauseofhumanischemicheartdisease.ThisstudywasdesignedtoinvestigatethehistopathologicfeaturesofTGHandPHTrabbits.TGHrabbitsshowedadvancedaorticatherosclerosis,accompaniedbyintimalthickeningofcoronaryandrenalarteries,fattyliverchanges,andxanthoma.PHTrabbitsdemonstratedaorticintimalthickeningandhepaticfattydegeneration.TheresultsofthisstudysuggestthatTGHandPHTrabbitsareusefulanimalmodelsforstudyinghumanhyperlipidemiaandmetabolicsyndromeandthecardiovasculardiseasesthatresultfromtheseconditions.

机译：Inrecentyears，theassociationbetweenhyperlipidemiaandthedevelopmentofarteriosclerosishasbeenaddressedinseveralstudies.Rabbitmodelsofhypertriglyceridemia（TGH）andpostprandialhypertriglyceridemia（PHT）havebeendevelopedattheauthors'institute.TGHrabbitsmanifestpathologysimilartothatofhumanswithTGH，suchasxanthoma，inadditiontoatherosclerosisofarterioles.Furthermore，PHTrabbitsshowvisceralobesity，胰岛素抵抗，andimpairedglucosetolerance，withpathologicfeaturessimilartothoseofthemetabolicsyndromeassumedtobethecauseofhumanischemicheartdisease.ThisstudywasdesignedtoinvestigatethehistopathologicfeaturesofTGHandPHTrabbits.TGHrabbitsshowedadvancedaorticatherosclerosis，accompaniedbyintimalthickeningofcoronaryandrenalarteries，fattyliverchanges，andxanthoma.PHTrabbitsdemonstratedaorticintimalthickeningandhepaticfattydegeneration.TheresultsofthisstudysuggestthatTGHandPHTrabbitsareusefulanimalmodelsforstudyinghumanhyperlipidemiaandmetabolicsyndromeandthecardiovasculardiseasesthatresultfromtheseconditions 。

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《Comparative Medicine》 |2008年第5期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Pathologic findings in rabbit models of hereditary hypertriglyceridemia and hereditary postprandial hypertriglyceridemia [J] . Mitsuguchi Y, Ito T, Ohwada K Comparative Medicine . 2008,第5期

机译：遗传性高甘油三酯血症和餐后遗传性高甘油三酯血症兔模型的病理发现
2. Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits (vol 53, pg 114, 2013) [J] . Fukuda Naoki Journal of clinical biochemistry and nutrition. . 2014,第2期

机译：脂肪酸合成的上调和肝甘油三酸酯脂肪酶的抑制是家兔遗传性餐后高甘油三酯血症的直接原因（第53卷，第114页，2013年）
3. Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits [J] . Fukuda Naoki, Ito Tsunekata, Ohwada Kazuo, Journal of clinical biochemistry and nutrition. . 2013,第2期

机译：脂肪酸合成的上调和肝甘油三酸酯脂肪酶的抑制是家兔遗传性餐后高甘油三酯血症的直接原因
4. Prophylactic total gastrectomy for hereditary diffuse gastric cancer: surgical and pathological results [C] . S.S. Yoon, D. Patel, D.C. Chung, International Gastric Cancer Congress . 2009

机译：预防遗传性胃癌的预防性总胃切除术：外科手术和病理结果
5. Mechanisms of hypertriglyceridemia and relation to aortic lesion in the coconut oil/cholesterol-fed rabbit [D] . Van Heek, Margaret 1990

机译：椰子油/胆固醇喂养的兔高甘油三酸酯血症的机制及其与主动脉病变的关系
6. Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits [O] . Naoki Fukuda, Tsunekata Ito, Kazuo Ohwada, 2013

机译：脂肪酸合成的上调和肝甘油三酸酯脂肪酶的抑制是家兔遗传性餐后高甘油三酯血症的直接原因
7. Upregulation of fatty acid synthesis and the suppression of hepatic triglyceride lipase as a direct cause of hereditary postprandial hypertriglyceridemia in rabbits [O] . Naoki Fukuda, Tsunekata Ito, Kazuo Ohwada, 2013

机译：脂肪酸合成的上调及抑制肝甘油三酯脂肪酶作为兔遗传性后甘油三酯血症的直接原因

Pathologic Findings in Rabbit Models of Hereditary Hypertriglyceridemia and Hereditary Postprandial Hypertriglyceridemia

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