Comparative Analyses of Single-Nucleotide Polymorphisms in the TNF Promoter Region Provide Further Validation for the Vervet Monkey Model of Obesity

Gray Stanton B; Howard Timothy D; Langefeld Carl D; Hawkins Gregory A; Diallo Abdoulaye F; Wagner Janice D

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Comparative Analyses of Single-Nucleotide Polymorphisms in the TNF Promoter Region Provide Further Validation for the Vervet Monkey Model of Obesity

机译：TNF启动子区域中单核苷酸多态性的比较分析为肥胖的黑长尾猴模型提供了进一步的验证

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Tumornecrosisfactorisacytokinethatplayscriticalrolesininflammation,theinnateimmuneresponse,andavarietyofotherphysiologicandpathophysiologicprocesses.Inaddition,TNFhasrecentlybeenshowntomediateanintersectionofchronic,low-gradeinflammationandconcurrentmetabolicdysregulationassociatedwithobesityanditscomorbidities.AspartofanongoinginitiativetofurthercharacterizevervetmonkeysoriginatingfromStKittsasananimalmodelofobesityandinflammation,wesequencedandgenotypedthehumanorthologvervetTNFgeneandapproximately1kboftheflanking3#8242;and5#8242;regionsfrom265monkeysinaclosed,pedigreedcolony.Thisprocessrevealedatotalof11single-nucleotidepolymorphisms(SNPs)andasingle4-bpinsertion#8211;deletion,withminorallelefrequenciesof0.08to0.39.Manyofthesepolymorphismswereinstrongorcompletelinkagedisequilibriumwitheachother,andallbut1werecontainedwithinasinglehaplotypeblock,comprising5haplotypeswithfrequenciesof0.075to0.298.Usingsequencesfromhumans,chimpanzees,vervets,baboons,andrhesusmacaques,phylogeneticshadowingoftheTNFpromoterregionrevealedthatvervetSNPs,liketheSNPsinrelatedspecies,wereclusterednonrandomlyandnonuniformlyaroundconservedtranscriptionfactorbindingsites.Thesedata,combinedwithpreviouslydefinedheritablephenotypes,permitfutureassociationanalysesinthisnonhumanprimatemodelandhavegreatpotentialtohelpdissectthegeneticandnongeneticcontributionstocomplexdiseaseslikeobesity.Morebroadly,thesequencedataandcomparativeanalysesreportedhereinfacilitatesstudyoftheevolutionofregulatorysequencesofinflammatoryandimmune-relatedgenes.

机译：Tumornecrosisfactorisacytokinethatplayscriticalrolesininflammation，theinnateimmuneresponse，andavarietyofotherphysiologicandpathophysiologicprocesses.Inaddition，TNFhasrecentlybeenshowntomediateanintersectionofchronic，低gradeinflammationandconcurrentmetabolicdysregulationassociatedwithobesityanditscomorbidities.AspartofanongoinginitiativetofurthercharacterizevervetmonkeysoriginatingfromStKittsasananimalmodelofobesityandinflammation，wesequencedandgenotypedthehumanorthologvervetTNFgeneandapproximately1kboftheflanking3＃8242; AND5＃8242; regionsfrom265monkeysinaclosed，pedigreedcolony.Thisprocessrevealedatotalof11single-nucleotidepolymorphisms（SNPs）的andasingle4-bpinsertion＃8211;缺失，withminorallelefrequenciesof0.08to0.39.Manyofthesepolymorphismswereinstrongorcompletelinkagedisequilibriumwitheachother，并且所有的1个都包含单个单元格类型块，包含5个单元格类型，频率为0.075至0.298。使用来自人类，黑猩猩，黑猩猩，狒狒，猕猴，猕猴，系统发生阴影的序列goftheTNFpromoterregionrevealedthatvervetSNPs，liketheSNPsinrelatedspecies，wereclusterednonrandomlyandnonuniformlyaroundconservedtranscriptionfactorbindingsites.Thesedata，combinedwithpreviouslydefinedheritablephenotypes，permitfutureassociationanalysesinthisnonhumanprimatemodelandhavegreatpotentialtohelpdissectthegeneticandnongeneticcontributionstocomplexdiseaseslikeobesity.Morebroadly，thesequencedataandcomparativeanalysesreportedhereinfacilitatesstudyoftheevolutionofregulatorysequencesofinflammatoryandimmune-relatedgenes。

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《Comparative Medicine》 |2009年第6期|共页
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Gray Stanton B; Howard Timothy D; Langefeld Carl D; Hawkins Gregory A; Diallo Abdoulaye F; Wagner Janice D;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Comparative Analyses of Single-Nucleotide Polymorphisms in the TNF Promoter Region Provide Further Validation for the Vervet Monkey Model of Obesity. [J] . Gray Stanton B., Howard Timothy D., Langefeld Carl D., Comparative Medicine . 2009,第6期

机译：TNF启动子区域中的单核苷酸多态性的比较分析为肥胖的黑长尾猴模型提供了进一步的验证。
2. Single-nucleotide polymorphisms in the TNF gene are associated with obesity-related phenotypes in vervet monkeys. [J] . Gray SB, Langefeld CD, Ziegler JT, Obesity . 2011,第7期

机译：TNF基因中的单核苷酸多态性与黑长尾猴中与肥胖相关的表型有关。
3. Association of TNF-alpha and TNFR1 promoters and 3' UTR region of TNFR2 gene polymorphisms with genetic susceptibility to tobacco-related oral carcinoma in Asian Indians. [J] . Gupta R, Sharma SC, Das SN Oral oncology . 2008,第5期

机译：TNF-α和TNFR1启动子以及TNFR2基因多态性的3'UTR区与亚洲印第安人与烟草相关的口腔癌的遗传易感性相关。
4. Further Evidence for Role of Promoter Polymorphisms in TNF Gene in Alzheimer's Disease [C] . Yannan Bin, Ling Shu, Qizhi Zhu, International conference on intelligent computing . 2018

机译：阿尔茨海默氏病中TNF基因启动子多态性作用的进一步证据
5. Dissecting anxiety in the vervet monkey: A search for association between polymorphisms in the corticotropin releasing hormone (CRH) and neuropeptide Y (NPY) genes and anxious behavior. [D] . Elbejjani, Martine. 2007

机译：剖析黑长尾猴中的焦虑症：寻找促肾上腺皮质激素释放激素（CRH）和神经肽Y（NPY）基因多态性与焦虑行为之间的联系。
6. Comparative Analyses of Single-Nucleotide Polymorphisms in the TNF Promoter Region Provide Further Validation for the Vervet Monkey Model of Obesity [O] . Stanton B Gray, Timothy D Howard, Carl D Langefeld, 2009

机译：TNF启动子区域中单核苷酸多态性的比较分析为肥胖的黑长尾猴模型提供了进一步的验证
7. Effect of single-nucleotide polymorphisms －705T/C and －603T/A in P1 promoter region of human insulin-like growth factor-I gene on promoter activity [O] . Wei HUANG, Leung-sang TANG, Yu-li WANG, 2012

机译：单核苷酸多态性-705T / C和-603T / a对人胰岛素样生长因子-I基因p1启动子区启动子活性的影响

Comparative Analyses of Single-Nucleotide Polymorphisms in the TNF Promoter Region Provide Further Validation for the Vervet Monkey Model of Obesity

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