Ovine Model for Critical-Size Tibial Segmental Defects

Christou Chris; Oliver Rema A; Pelletier Matthew H; Walsh William R

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Ovine Model for Critical-Size Tibial Segmental Defects

机译：关键性胫骨节段性缺损的绵羊模型

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Asegmentaltibialdefectmodelinalargeanimalcanprovideabasisfortestingmaterialsandtechniquesforuseinnonunionsandseveretrauma.Thisstudyreportstherationalebehindestablishingsuchamodelanditsdesignandconclusions.Afterethicsapprovalofthestudy,agedewes(olderthan5y;n=12)wereenrolled.A5-cmmiddiaphysealosteoperiostealdefectwasmadeinthelefttibiaandwasstabilizedbyusingan8-mmstainless-steelcross-lockedintramedullarynail.Sheepwereeuthanizedat12wkaftersurgeryandevaluatedbyusingradiography,microCT,andsoft-tissuehistologytechniques.Radiologyconfirmedalackofhardtissuecallusbridgingacrossthedefect.VolumetricanalysisbasedonmicroCTshowedbonegrowthacrossthe16.5cmsup3/supdefectof1.82±0.94cmsup3/sup.Histologicsectionsofthebridgingtissuesrevealedcallusoriginatingfromboththeperiostealandendostealsurfaces,withfibroustissuecompletingthebridginginallinstances.Immunohistochemistrywasusedtoevaluatethequalityofthehealingresponse.Clinical,radiographic,andhistologicunionwasnotachievedby12wk.Thismodelmaybeeffectivefortheinvestigationofsurgicaltechniquesandhealingadjunctsfornonunioncases,whereseveretraumaticinjuryhasledtosignificantboneloss.

机译：Asegmentaltibialdefectmodelinalargeanimalcanprovideabasisfortestingmaterialsandtechniquesforuseinnonunionsandseveretrauma.Thisstudyreportstherationalebehindestablishingsuchamodelanditsdesignandconclusions.Afterethicsapprovalofthestudy，agedewes（olderthan5y; N = 12）wereenrolled.A5-cmmiddiaphysealosteoperiostealdefectwasmadeinthelefttibiaandwasstabilizedbyusingan8-mmstainless-steelcross-lockedintramedullarynail.Sheepwereeuthanizedat12wkaftersurgeryandevaluatedbyusingradiography，显微CT，andsoft-tissuehistologytechniques.Radiologyconfirmedalackofhardtissuecallusbridgingacrossthedefect.VolumetricanalysisbasedonmicroCTshowedbonegrowthacrossthe16.5cm ^{3 defectof1.82 ±0.94cm 3 。组织学切片示于骨膜的软骨丛组织，形成于骨膜的两个骨膜表面，并伴有纤维性的纤维组织，以弥补桥接的局限性。免疫组织化学被用于评估此治疗的临床和临床疗效，这是临床上所希望的。用于针对不愈合病例的外科手术技术和愈合辅助工具的调查，其中严重的外伤导致严重的骨丢失。}

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《Comparative Medicine》 |2014年第5期|共页
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Christou Chris; Oliver Rema A; Pelletier Matthew H; Walsh William R;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Ovine Model for Critical-Size Tibial Segmental Defects [J] . Christou Chris, Oliver Rema A., Pelletier Matthew H., Comparative Medicine . 2014,第5期

机译：关键性胫骨节段性缺损的绵羊模型
2. Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies. [J] . Reichert JC, Epari DR, Wullschleger ME, Tissue engineering, Part B. Reviews . 2010,第1期

机译：通过应用骨组织工程策略建立胫骨节段性骨缺损修复的临床前绵羊模型。
3. The efficacy of allogeneic mesenchymal precursor cells for the repair of an ovine tibial segmental defect. [J] . Field JR, McGee M, Stanley R, Veterinary and Comparative Orthopaedics and Traumatology . 2011,第2期

机译：同种异体间充质前体细胞修复羊胫节节段缺损的功效。
4. Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of an ovine critical-sized segmental tibial bone defect [C] . Arne Berner, Johannes C. Reichert, Maria A. Woodruff, World biomaterials congress . 2012

机译：自体vs.同种异体间充质祖细胞用于绵羊临界大小的节段性胫骨骨缺损的重建
5. Evaluation of a segmental titanium implant for mandibular reconstruction using a critical size defect model in the dog---a pilot study. [D] . Ricker, Zachary Hunter. 2009

机译：使用狗中的临界尺寸缺损模型评估分段式钛种植体用于下颌骨重建的一项先导研究。
6. Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis [O] . Mathieu Manassero, Adeline Decambron, Bui Truong Huu Thong, 2016

机译：板骨合成稳定小鼠节段性股骨临界大小缺损模型的建立
7. A New, Segmental, Critical-size Defect Model for Long Bones: A Sheep Study [O] . 2016

机译：一种新的，分段的，临界尺寸的长骨缺陷模型：绵羊研究

Ovine Model for Critical-Size Tibial Segmental Defects

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