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首页> 外文期刊>Comparative Medicine >Characterization of Ovarian Aging and Reproductive Senescence in Vervet Monkeys (Chlorocebus aethiops sabaeus)
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Characterization of Ovarian Aging and Reproductive Senescence in Vervet Monkeys (Chlorocebus aethiops sabaeus)

机译：黑长尾猴（Chlorocebus aethiops sabaeus）卵巢衰老和生殖衰老的特征

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Femalevervetmonkeys(Chlorocebusaethiopssabaeus)areusedasanexperimentalmodelforchronicdiseasesrelevanttowomen'shealth.However,reproductivesenescence(menopause)hasnotyetbeencharacterizedforvervetmonkeys.Herewedescribethehistologic,hormonal,andmenstrualmarkersofreproductivesenescenceinvervetmonkeysfromtheWakeForestVervetResearchColony.Ovariesfrommonkeys(age,0to27y)wereseriallysectioned(5#956;m),stained,andphotographed.Inevery100thsection,thenumbersofprimordial,primary,andsecondaryfolliclesweredetermined,andtriplicatemeasurementswereusedtocalculatemeannumbersoffolliclesperovary.Antimüllerianhormone(AMH),folliclestimulatinghormone,andmenstrualcyclelengthweremeasuredinadditionalmonkeys.PrimordialfolliclesandAMHdecreasedsignificantlywithage,andsignificantcorrelationsbetweennumbersofprimordialandprimaryfolliclesandbetweennumbersofprimaryandsecondaryfollicleswerenoted.Histologicevaluationrevealedthatovariesfrom4agedmonkeys(olderthan23y)weresenescent.Oneagedmonkeytransitionedtomenopause,experiencingcycleirregularityover4y,eventualcessationofmenses,andplasmaAMHbelowthelevelofdetection.Finally,withincreasingage,thepercentageoffemalevervetswithoffspringdeclinedsignificantly.Thepresentstudyprovidesinsightintoovarianagingandreproductivesenescenceinvervetmonkeys.Resultshighlighttheimportanceofconsideringthisnonhumanprimateasamodeltoinvestigatetherelationshipsbetweenovarianagingandchronicdiseaserisk.
机译：Femalevervetmonkeys（Chlorocebusaethiopssabaeus）areusedasanexperimentalmodelforchronicdiseasesrelevanttowomen'shealth.However，reproductivesenescence（更年期）hasnotyetbeencharacterizedforvervetmonkeys.Herewedescribethehistologic，激素，andmenstrualmarkersofreproductivesenescenceinvervetmonkeysfromtheWakeForestVervetResearchColony.Ovariesfrommonkeys（年龄，0to27y）wereseriallysectioned（5＃956; M），染色，andphotographed.Inevery100thsection，thenumbersofprimordial，伯，andsecondaryfolliclesweredetermined，andtriplicatemeasurementswereusedtocalculatemeannumbersoffolliclesperovary .Antimüllerianhormone（AMH），folliclestimulatinghormone，andmenstrualcyclelengthweremeasuredinadditionalmonkeys.PrimordialfolliclesandAMHdecreasedsignificantlywithage，andsignificantcorrelationsbetweennumbersofprimordialandprimaryfolliclesandbetweennumbersofprimaryandsecondaryfollicleswerenoted.Histologicevaluationrevealedthatovariesfrom4agedmonkeys（olderthan23y）weresenescent.Oneagedmonkeytransitionedtomenopause，experien最终，随着月经周期的不规律性，月经的停止和血浆AM的检出水平降低。最后，随着年龄的增长，后代的雌蜂的百分比显着下降。本研究提供了一种模式，以期对人类和繁殖衰老的研究表明其重要性。

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