Mouse Models of Aerosol-Acquired Tularemia Caused by Francisella tularensis Types A and B

Fritz David L; England Marilyn J; Miller Lynda; Waag David M

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Mouse Models of Aerosol-Acquired Tularemia Caused by Francisella tularensis Types A and B

机译：图拉弗朗西斯菌A型和B型引起的气溶胶性Tularemia的小鼠模型

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AfterpreliminaryassessmentofvirulenceinAKR/J,DBA/1,BALB/c,andC57BL/6mice,weinvestigatedhistopathologicchangesinBALB/candC57BL/6miceinfectedwithtypeA(strainSCHUS4)ortypeB(strain425)Francisellatularensisbyaerosolexposure.InmiceexposedtotypeAinfection,changesinhistologicpresentationwerenotapparentuntilday3afterinfection,whenpyogranulomatousinflammationwasdetectedinspleensandliversofBALB/cmice,andinlungsandspleensofC57BL/6mice.Histopathologicchangesweremostsevereandwidespreadinbothmousestrainsonday5afterinfectionandseemedtocompletelyresolvewithin22dofchallenge.BALB/cmiceweremoreresistantthanC57BL/6miceinlethal-dosecalculations,butC57BL/6miceclearedtheinfectionmorerapidly.MicesimilarlychallengedwithtypeBF.tularensisalsodevelopedhistopathologicsignsofinfectionbeginningonday3.Themostseverechangeswerenotedonday8andwerecharacterizedbygranulomatousorpyogranulo-matousinfiltrationsofthelungs.UnliketypeAinfection,lesionsduetotypeBdidnotresolveovertimeandremained3wkafterinfection.IntypeB,butnottypeA,infectionwenotedextensiveinflammationoftheheartmuscle.AlthoughnomicroorganismswerefoundintissuesoftypeAsurvivorsbeyond9dafterinfection,micesurvivingstrain425infectionhadalowlevelofresidualinfectionat3wkafterchallenge.ThehistopathologicpresentationoftularemiacausedbyF.tularensistypesAandBinBALB/candC57BL/6micebearsdistinctsimilaritiestotularemiainhumans.

机译：AfterpreliminaryassessmentofvirulenceinAKR / J，DBA / 1，只BALB / c，andC57BL / 6mice，weinvestigatedhistopathologicchangesinBALB / candC57BL / 6miceinfectedwithtypeA（strainSCHUS4）ortypeB（strain425）Francisellatularensisbyaerosolexposure.InmiceexposedtotypeAinfection，changesinhistologicpresentationwerenotapparentuntilday3afterinfection，whenpyogranulomatousinflammationwasdetectedinspleensandliversofBALB / cmice，andinlungsandspleensofC57BL / 6mice.Histopathologicchangesweremostsevereandwidespreadinbothmousestrainsonday5afterinfectionandseemedtocompletelyresolvewithin22dofchallenge.BALB / cmiceweremoreresistantthanC57BL / 6miceinlethal-剂量计算，但C57BL / 6小鼠能更迅速地清除感染。同样，受到BF.tularensis攻击的小鼠也从3日开始就出现了组织病理学上的标志感染。值得注意的是，第8天的变化最为明显，并且通过3型肉芽肿或脓性肉芽肿没有被重新感染，但仍以不溶性的方式重新形成了，而3型仍以不溶性的方式重新感染，但仍以相同的方式被感染。，尽管我们没有发现感染后第9天的A型幸存者的微生物，但在挑战后第3周仍存活了425株感染力，而3种相似的结核病的组织病理学表现。

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《Comparative Medicine》 |2014年第5期|共页
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Fritz David L; England Marilyn J; Miller Lynda; Waag David M;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Mouse Models of Aerosol-Acquired Tularemia Caused by Francisella tularensis Types A and B [J] . Fritz David L., England Marilyn J., Miller Lynda, Comparative Medicine . 2014,第5期

机译：图拉弗朗西斯菌A型和B型引起的气溶胶性Tularemia的小鼠模型
2. Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen [J] . Shen H, Chen WX, Conlan JW Vaccine . 2004,第17a18期

机译：用致病性减毒活疫苗株免疫之前和之后，各种鼠株对强毒A型弗朗西斯菌的系统性或气溶胶性Tularemia的易感性
3. A Bioluminescent Francisella tularensis SCHU S4 Strain Enables Noninvasive Tracking of Bacterial Dissemination and the Evaluation of Antibiotics in an Inhalational Mouse Model of Tularemia [J] . Hall Charlotte A., Flick-Smith Helen C., Harding Sarah V., Antimicrobial agents and chemotherapy. . 2016,第12期

机译：生物发光的弗朗西斯菌tularensis SCHU S4菌株能够以无创方式跟踪细菌传播，并在吸入性Tularemia小鼠模型中评估抗生素
4. Lipid A Remodeling by N-acyltransferases in Francisella tularensis Elucidated by QIT-TOF and LTQ Orbitrap Hybrid Mass Spectrometers [C] . Scott A. Shaffer, John D. Leszyk, Yanyan Li, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：通过QIT-TOF和LTQ杂交杂交质谱仪阐明的菌丝氏细胞中的N-酰基转移酶进行重塑。
5. Francisella tularensis Outer Membrane Protein A (FopA) as a Protective Antigen in Mice for Tularemia [D] . Hickey, Anthony J. 2011

机译：图拉弗朗西斯菌外膜蛋白A（FopA）作为图拉血症小鼠的保护性抗原
6. A ΔclpB Mutant of Francisella tularensis Subspecies holarctica Strain FSC200 Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia [O] . Igor Golovliov, Susan M. Twine, Hua Shen, -1

机译：图莱弗朗西斯菌亚种holarctica菌株的ΔclpB突变体FSC200是比图莱弗氏LVS更有效的活疫苗适用于图莱姆病小鼠呼吸挑战模型
7. A Delta clpB Mutant of Francisella tularensis Subspecies holarctica Strain, FSC200, Is a More Effective Live Vaccine than F. tularensis LVS in a Mouse Respiratory Challenge Model of Tularemia [O] . Golovlev, Igor, Twine, Susan M., Shen, Hua, 2013

机译：图莱弗朗西斯菌亚种holarctica株，FSC200的ΔclpB突变体是比图莱弗氏LVS更有效的活疫苗，用于图莱姆病小鼠呼吸挑战模型

Mouse Models of Aerosol-Acquired Tularemia Caused by Francisella tularensis Types A and B

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