Long-Term Repeated Daily Use of Intragastric Gavage Hinders Induction of Oral Tolerance to Ovalbumin in Mice

Kinder Jeremy M; Then Jenny E; Hansel Patrick M; Molinero Luciana L; Bruns Heather A

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Long-Term Repeated Daily Use of Intragastric Gavage Hinders Induction of Oral Tolerance to Ovalbumin in Mice

机译：长期反复每日多次使用胃管灌胃可诱导小鼠对卵清蛋白的耐受性

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Oraltoleranceisdependentonthecomplexarchitectureofthemucosalsystemofthegastrointestinaltract,itsassociatedlymphoidtissue,andspecializedimmunecells.Changesinthisarchitectureorthefailureofanyofitscomponentsmayhinderthegenerationoforaltolerance.Thelarynxandesophagusarethegatewaytothegastrointestinaltract,servingasthesiteoforalantigenintroductiontotheimmunesystemandmayhaveanimportantroleinestablishingtolerance.Intragastricgavageisacommonmethodforpreciseoraldosingofrodents,particularlyinstudiesexaminingoraltolerance.However,complicationssuchasesophagealtraumacanoccurandinducecomplicatingfactorsthataffectexperimentaloutcomes.Inthisstudy,weexaminedtheesophagealepitheliumforalterationsresultingfromlong-termrepeateddailyuseofintragrastricgavageanditseffectontheinductionoftolerance.Tolerancetoovalbumincouldnotbeachievedafterusingintragastricgavagefor14dormoreconsecutivelytointroduceovalbumin.However,tolerancewasachievedwhenintragastricgavagewasusedforshorterdurations.After14dofgavage,disruptionoftheesophagealmucosalepitheliumindicativeofaninflammatorypathology,cellularinfluxintotheesophagealtissue,andproinflam-matorycytokinesinthetissuewereabsent,andtheCD3sup+/supcellpopulationintheesophagealepitheliumdecreased.Thesefindingsprovideinitialevidencefortheimportantrolesofesophagealintegrityandcellularpopulationsintheinductionoforaltoleranceandsuggestpossibleimmunologicsequelaeinexperimentsinvolvingtheuseofextended,repeatedgavage.

机译：Oraltoleranceisdependentonthecomplexarchitectureofthemucosalsystemofthegastrointestinaltract，itsassociatedlymphoidtissue，andspecializedimmunecells.Changesinthisarchitectureorthefailureofanyofitscomponentsmayhinderthegenerationoforaltolerance.Thelarynxandesophagusarethegatewaytothegastrointestinaltract，servingasthesiteoforalantigenintroductiontotheimmunesystemandmayhaveanimportantroleinestablishingtolerance.Intragastricgavageisacommonmethodforpreciseoraldosingofrodents，particularlyinstudiesexaminingoraltolerance.However，complicationssuchasesophagealtraumacanoccurandinducecomplicatingfactorsthataffectexperimentaloutcomes.Inthisstudy，weexaminedtheesophagealepitheliumforalterationsresultingfromlong-termrepeateddailyuseofintragrastricgavageanditseffectontheinductionoftolerance.Tolerancetoovalbumincouldnotbeachievedafterusingintragastricgavagefor14dormoreconsecutivelytointroduceovalbumin.However，tolerancewasachievedwhenintragastricgavagewasusedforshorterdurations.After14dofgavage，disruptiono ftheesophagealmucosalepitheliumindicativeofaninflammatorypathology，cellularinfluxintotheesophagealtissue，andproinflam-matorycytokinesinthetissuewereabsent，andtheCD3 ^{+ cellpopulationintheesophagealepitheliumdecreased.Thesefindingsprovideinitialevidencefortheimportantrolesofesophagealintegrityandcellularpopulationsintheinductionoforaltoleranceandsuggestpossibleimmunologicsequelaeinexperimentsinvolvingtheuseofextended，repeatedgavage。}

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《Comparative Medicine》 |2014年第5期|共页
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Kinder Jeremy M; Then Jenny E; Hansel Patrick M; Molinero Luciana L; Bruns Heather A;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Long-Term Repeated Daily Use of Intragastric Gavage Hinders Induction of Oral Tolerance to Ovalbumin in Mice [J] . Kinder Jeremy M., Then Jenny E., Hansel Patrick M., Comparative Medicine . 2014,第5期

机译：长期反复每日多次使用胃管管饲法诱导小鼠对卵清蛋白的耐受性
2. Genetic Selection for Resistance or Susceptibility to Oral Tolerance to Ovalbumin Affects General Mechanisms of Tolerance Induction in Mice [J] . ALICE O. KAMPHORST, MARIA F. S. DA SILVA, ANTONIO C. DA SILVA, Annals of the New York Academy of Sciences . 2004,第Dec期

机译：对卵清蛋白的口服耐受性或易感性的遗传选择影响小鼠耐受性诱导的一般机制
3. Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice [J] . de Molon Rafael Scaf, Mascarenhas Vinicius Ibiapina, de Avila Erica Dorigatti, Clinical oral investigations . 2016,第6期

机译：长期评估小鼠牙周病原体或结扎诱导实验性牙周疾病
4. Induction of Proliferative Lesions of the Uterus, Testes and Liver in Swiss Mice Given Repeated Injections of Sodium Arsenate [C] . Bhalchandra A. Diwan, Larry K. Keefer, Michael P. Waalkes International conference on arsenic exposure and health effects . 2001

机译：诱导瑞士小鼠的子宫，睾丸和肝脏的增殖性病变，所述瑞士小鼠重复注射砷酸钠
5. Investigating diclofenac-specific sensitivity and tolerance following oral exposure in BALB/c mice using the potential lymph node assay. [D] . Gutting, Bradford Wesley. 2001

机译：使用潜在的淋巴结试验研究BALB / c小鼠口服暴露后双氯芬酸的特异性敏感性和耐受性。
6. Long-Term Repeated Daily Use of Intragastric Gavage Hinders Induction of Oral Tolerance to Ovalbumin in Mice [O] . Jeremy M Kinder, Jenny E Then, Patrick M Hansel, 2014

机译：长期反复每日使用胃管管饲法诱导小鼠对卵清蛋白的耐受性
7. Erythromycin treatment hinders the induction of oral tolerance to fed ovalbumin [O] . Sydney E. Lambert, Jeremy M. Kinder, Jenny E. Then, 2012

机译：红霉素处理阻碍了对饲喂卵清蛋白的口服耐受性的诱导
8. Acute and Repeated Dose Toxicity Studies on Nsc 94100 Following Daily Oral Administration to Dogs and Monkeys and Acute Toxicity Following Oral Administration to Mice and Monkeys [R] . Rakieten, N., Schein, P. S., Davis, R. D. 1967

机译：Nsc 94100的急性和重复剂量毒性研究对狗和猴进行每日口服给药后口服给予小鼠和猴子的急性毒性

Long-Term Repeated Daily Use of Intragastric Gavage Hinders Induction of Oral Tolerance to Ovalbumin in Mice

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