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首页> 外文期刊>Comparative and functional genomics >Reductive Evolution in Bacteria:Buchnerasp.,Rickettsia prowazekiiandMycobacterium leprae
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Reductive Evolution in Bacteria:Buchnerasp.,Rickettsia prowazekiiandMycobacterium leprae

机译：细菌的还原性进化：Buchnerasp。，Rickettsia prowazekiiand麻风分枝杆菌

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摘要

Obligate intracellular bacteria commonly have much reduced genome sizes compared totheir nearest free-living relatives. One reason for this is reductive evolution: the loss ofgenes rendered non-essential due to the intracellular habitat. This can occur because of thepresence of orthologous genes in the host, combined with the ability of the bacteria toimport the protein or metabolite products of the host genes. In this article we take a lookat three such bacteria whose genomes have been fully sequenced.Buchnerais anendosymbiont of the pea aphid,Acyrthosiphon pisum, the relationship between these twoorganisms being so essential that neither can reproduce in the absence of the other.Rickettsia prowazekiiis the causative agent of louse-borne typhus in humans andMycobacterium lepraeinfection of humans leads to leprosy. Both of these humanpathogens have fastidious growth requirements, which has made them very difficult tostudy.
机译：与它们最接近的自由生活亲戚相比，专性细胞内细菌通常具有大大减少的基因组大小。其原因之一是还原性进化：由于细胞内栖息地而使基因丧失变得不必要。这可能是由于宿主中存在直系同源基因，以及细菌导入宿主基因的蛋白质或代谢产物的能力所致。在本文中，我们研究了三个这样的细菌，它们的基因组已被完全测序。豌豆蚜虫的无内生细菌，两个细菌之间的关系是如此重要，以至于两个细菌在没有另一个细菌的情况下都无法繁殖。鼠源性斑疹伤寒的致病因子和人类分枝杆菌的麻风感染会导致麻风病。这两种人类病原体都具有严格的生长要求，这使得它们的研究非常困难。

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