Prevalence of Enterotropic and Polytropic Mouse Hepatitis Virus in Enzootically Infected Mouse Colonies

Homberger Felix R.; Zhang Linong; Barthold Stephen W.

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Prevalence of Enterotropic and Polytropic Mouse Hepatitis Virus in Enzootically Infected Mouse Colonies

机译：肠道和多型小鼠肝炎病毒在感染动物的菌落中的流行

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Mousehepatitisvirus(MHV)causesthemostprevalentviralinfectionincontemporarylaboratorymousecolonies.Accordingtotheirprimaryreplicationsite,differentstrainsofMHVsegregateintotwooverlappingbiotypes,enterotropicandpolytropic.Thesetwogroupsvarygreatlyindiseasepattern,pathogenicity,immuneresponse,anddurationofinfection.Historically,thepolytropicMHVstrainsrepresenttheextensivelystudiedprototypestrainsthathaveminimalenterotropism,whereasenterotropicMHVstrainshavebeenlesscharacterized.AnecdotalreportssuggestthatmostMHVstrainsencounteredtodaybelongtotheenterotropicbiotype.Wehaveidentified15isolatesofMHVfrom19independentenzooticallyinfectedmousecolonies.Sequencingofavariableregionofthenucleoprotein(N)geneofeachisolateconfirmedthatallwereindependentgeneticvariants.Theprincipaltissuetropismofthenewisolateswasdeterminedbyexperimentalinoculationofinfantmiceandexaminationofintestine,liver,spleen,andbrainforlesions.Nineisolatesinfectedonlyintestine;fourisolatesinfectedintestineandliver;oneisolateinfectedintestine,liver,andbrain;andoneisolateinfectedliver.TheseresultsconfirmthattheenterotropicMHVbiotypeispredominantincontemporarylaboratorymousecolonies.TheMHVbiotypefeaturesneedtobetakenintoconsiderationwhendealingwithMHVinfections.

机译：Mousehepatitisvirus（MHV）causesthemostprevalentviralinfectionincontemporarylaboratorymousecolonies.Accordingtotheirprimaryreplicationsite，differentstrainsofMHVsegregateintotwooverlappingbiotypes，enterotropicandpolytropic.Thesetwogroupsvarygreatlyindiseasepattern，致病性，免疫应答，anddurationofinfection.Historically，thepolytropicMHVstrainsrepresenttheextensivelystudiedprototypestrainsthathaveminimalenterotropism，whereasenterotropicMHVstrainshavebeenlesscharacterized.AnecdotalreportssuggestthatmostMHVstrainsencounteredtodaybelongtotheenterotropicbiotype.Wehaveidentified15isolatesofMHVfrom19independentenzooticallyinfectedmousecolonies.Sequencingofavariableregionofthenucleoprotein（N）geneofeachisolateconfirmedthatallwereindependentgeneticvariants.Theprincipaltissuetropismofthenewisolateswasdeterminedbyexperimentalinoculationofinfantmiceandexaminationofintestine，肝，脾，andbrainforlesions.Nineisolatesinfectedonlyintestine; fourisolatesinfectedintestineandliver; oneisolateinfecte结果证实在同一个实验室小鼠群体中，嗜性MHV生物型主要存在于肠道。

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《Comparative Medicine》 |1998年第1期|共页
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Homberger Felix R.; Zhang Linong; Barthold Stephen W.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies [J] . Homberger FR, Zhang LiNong, Barthold SW Laboratory Animal Science . 1998,第1期

机译：肠道和多形性小鼠肝炎病毒在感染动物的小鼠菌落中的流行
2. Replication of Enterotropic and Polytropic Murine Coronaviruses in Cultured Cell Lines of Mouse Origin [J] . Shigeru Kyuwa, Kazutaka Ohsawa, Hiroshi Sato Experimental Animals . 2000,第4期

机译：肠道和多向鼠冠状病毒在小鼠起源的培养细胞系中的复制。
3. Characterization of Mouse Parvovirus Infection Among BALB/c Mice from an Enzootically Infected Colony [J] . Shek William R., Paturzo Frank X., Johnson Elizabeth A., Comparative Medicine . 1998,第3期

机译：小鼠细小病毒感染的感染的殖民地BALB / c小鼠之间的表征。
4. Prevalence of Skin diseases among Hepatitis C virus infected patients and their association with HCV infection in Islamabad, Pakistan [C] . Zujaja tul Misbah, Lubaba tul Uzma, Kanwal Shaheen, International Bhurban Conference on Applied Sciences and Technology . 2019

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5. Identification of anti-inflammatory constituents in Hypericum species and unveiling the underlying mechanism in LPS-stimulated mouse macrophages and H1N1 influenza virus infected BALB/c mouse. [D] . Huang, Nan. 2011

机译：鉴定金丝桃属植物中的抗炎成分，并揭示了LPS刺激的小鼠巨噬细胞和H1N1流感病毒感染的BALB / c小鼠的潜在机制。
6. Nucleotide sequence comparison of the membrane protein genes of three enterotropic strains of mouse hepatitis virus [O] . F.R. Hornberger -1

机译：三种小鼠肠型肠炎病毒肠膜蛋白基因的核苷酸序列比较
7. RT-PCR Assay for Detection of Enterotropic Strains of Mouse Hepatitis Virus in Faecal Samples [O] . M.R. Srinivasan, K. Vijay, A.K. Karuppannan, 2021

机译：RT-PCR测定检测粪便样品中小鼠肝炎病毒的肠胃肠菌株
8. Eradication of Mouse Hepatitis Virus from a Breeding and a Research Colony [R] . Bingham, G. A. 1986

机译：从育种和研究群体中根除小鼠肝炎病毒

Prevalence of Enterotropic and Polytropic Mouse Hepatitis Virus in Enzootically Infected Mouse Colonies

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