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首页> 外文期刊>Comparative Medicine >Experimentally Induced Pneumonia in scid/beige Mice, Using a Bovine Isolate of Pasteurella haemolytica
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Experimentally Induced Pneumonia in scid/beige Mice, Using a Bovine Isolate of Pasteurella haemolytica

机译：使用溶血巴斯德氏菌的牛分离物，在实验动物/米色小鼠中诱发肺炎

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BackgroundandPurpose:IntranasalchallengeofimmunocompetentmicewithPasteurellahaemolyticaresultsinlittleornopulmonaryinflammation.Thestudyreportedherewasdesignedtoinvestigatetheinflammatoryresponseinthelungsofimmunodeficientscid/beigemiceaftersimilarchallenge.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Fifty-fivescid/beigemicewerechallengedintranasallywithsalineoroneofthreedoses(2.8x10supxmlns="http://pub2web.metastore.ingenta.coms/"6/sup,3.4x10supxmlns="http://pub2web.metastore.ingenta.coms/"9/sup,or3.3x10supxmlns="http://pub2web.metastore.ingenta.coms/"11/supcolony-formingunits[CFU]/ml)ofP.haemolytica.Thelungswereexaminedforchangesinweight,bacterialcount,andpresenceofgrossandmicroscopiclesionsat24,48,or96hoursafterchallenge.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Intranasalchallengewithconcentrations#8805;3.4x10supxmlns="http://pub2web.metastore.ingenta.coms/"9/supCFU/mlofP.haemolyticainducedsignificantlyheavierlungweight,withseverepulmonarylesions,anddevelopmentofsuppurativeandfibrinousbronchopneumoniaindose-andtime-dependentmanner48hoursafterchallenge.Pasteurellahaemolyticawasconsistentlyisolatedfromthelungsat24hoursafterchallenge.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:BronchopneumoniawasinducedbyP.haemolyticainmicewithoutmanipulationofthemouseorthebacteria.ThelesionsweresimilartothosethatdevelopinthelungsofcattleinfectedwithP.haemolyticaandindicatepotentialuseofthemodelforthestudyofthishost/bacterialinteraction.
机译：BackgroundandPurpose：IntranasalchallengeofimmunocompetentmicewithPasteurellahaemolyticaresultsinlittleornopulmonaryinflammation.Thestudyreportedherewasdesignedtoinvestigatetheinflammatoryresponseinthelungsofimmunodeficientscid / beigemiceaftersimilarchallenge 方法：将50-fivescid / beigemicewerechallengedintranasallywithsalineoroneofthreedoses（2.8×10 6 ，3.4x10 9 ，或3.3x10 < P.haemolytica的菌落形成单位[CFU] / ml）。检查了肺在24、48或96小时攻击后的重量，细菌计数和存在的毛刺和显微病变的变化。 结果：Incentasalchallengewithconcentrations＃8805; 3.4x10 9 CFU / mlofP.hemolytica引起的明显重肺8，withseverepulmonarylesions，anddevelopmentofsuppurativeandfibrinousbronchopneumoniaindose-andtime-dependentmanner48hoursafterchallenge.Pasteurellahaemolyticawasconsistentlyisolatedfromthelungsat24hoursafterchallenge 结论：BronchopneumoniawasinducedbyP.haemolyticainmicewithoutmanipulationofthemouseorthebacteria.ThelesionsweresimilartothosethatdevelopinthelungsofcattleinfectedwithP.haemolyticaandindicatepotentialuseofthemodelforthestudyofthishost / bacterialinteraction。

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