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Increased Dietary Fat Prevents Sleep Deprivation-induced Immune Suppression in Rats

机译:膳食脂肪增加阻止大鼠睡眠剥夺引起的免疫抑制

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BackgroundandPurpose:Fattyacidcompositionofrodentdietscanaffectbaselineimmunefunctionasmeasuredinvitroandinvivo.Stress,inavarietyofforms,canalsoaffectimmunefunction.Possibleinteractionbetweendietandotherstressorshasnotbeenfullyexplored.Weexaminedtheinteractionbetweensleepdeprivationstressanddietaryfattyacidcompositioninalteringlymphocyteresponsestomitogenstimulation.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Ratswerefeddietscontainingvarioussourcesoffattyacids,thenweresubjectedtosleepdeprivation.Splenocyteswereharvestedandassayedforresponsivenesstovariousmitogens,usinga72-hproliferationassay.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Ratssubjectedtosleepdeprivationexperiencedsignificantsuppressionofinvitroproliferativeresponsetovariousmitogens.Thisimmunesuppressionwasdependentondurationofsleepdeprivation.Feedingsleepdeprivedratsadietenrichedinfattyacidsabrogatedtheeffectofsleepdeprivation.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Thefatcontentofrodentdietscanhaveamarkedeffectonbaselineandstress-modulatedimmuneresponses.
机译:BackgroundandPurpose:Fattyacidcompositionofrodentdietscanaffectbaselineimmunefunctionasmeasuredinvitroandinvivo.Stress,inavarietyofforms,canalsoaffectimmunefunction.Possibleinteractionbetweendietandotherstressorshasnotbeenfullyexplored.Weexaminedtheinteractionbetweensleepdeprivationstressanddietaryfattyacidcompositioninalteringlymphocyteresponsestomitogenstimulation 方法:Ratswerefeddietscontainingvarioussourcesoffattyacids,thenweresubjectedtosleepdeprivation.Splenocyteswereharvestedandassayedforresponsivenesstovariousmitogens,usinga72-hproliferationassay。 结果:经受了睡眠剥夺的老鼠受到了显着的对内营养的抑制作用,这种免疫抑制取决于睡眠剥夺的持续时间。 “>

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