Effects of Buprenorphine on Immunogenicity and Protective Efficacy in the Guinea Pig Keratoconjunctivitis Model (Sereny Test)

Hanson Chris E.; Ruble Gaye R.; Essiet Idongesit; Hartman Antoinette B.

首页> 外文期刊>Comparative Medicine >Effects of Buprenorphine on Immunogenicity and Protective Efficacy in the Guinea Pig Keratoconjunctivitis Model (Sereny Test)

【24h】

Effects of Buprenorphine on Immunogenicity and Protective Efficacy in the Guinea Pig Keratoconjunctivitis Model (Sereny Test)

机译：丁丙诺啡对豚鼠角膜结膜炎模型的免疫原性和保护功效的影响（Sereny试验）

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Shigellosisisadiseaseofglobalproportions,withanestimated164.7millionepisodesannuallythroughouttheworldaswellasanestimated1.1millionassociatedmortalitiesindevelopingcountries.Duetoincreasingincidence,andcontinuedemergenceofmulti-drugresistantstrains,Shigellavaccinedevelopmentisconsideredatoppublichealthpriority.Theguineapigkeratoconjunctivitismodel,thebasisfortheSerenytest,remainsthemostreliableinvivoindicatorofvirulenceofShigellastrainsandimmunogenicityandprotectiveefficacyofShigellavaccinecandidates.ThemodeliseffectiveinevaluatingtheabilityofShigellastrainstoinvadethecornealepitheliaofguineapigsandspreadtocontiguouscells,withthemorevirulentstrainscausingulcerativekeratoconjunctivitis.However,analgesiaisnotroutinelyusedtorelievethispainfulconditionbecauseofpotentialimmunomodulationandconfoundingofexperimentalresults.TheobjectiveofthestudyreportedherewastoevaluateuseofbuprenorphinehydrochlorideasananalgesicduringtheSerenytest.Localandsystemicimmuneresponsesweremeasuredinguineapigsgivenbuprenorphineversusthoseresponsesincontrols.Resultsofthisstudysuggestthatbuprenorphine,administeredatananalgesicdoseof0.05mg/kgofbodyweighttwicedaily,canbesuccessfullyusedwiththemodelwithoutsignificantlyaffectingimmunologicevaluationofShigellavaccinecandidates.However,inbuprenorphine-treatedanimals,therewasasignificantincreaseintheamountofmucopurulentoculardischarge,requiringfrequentcleaningoftheaffectedeyes.Additionally,animalstreatedwithbuprenorphinehadsignificantreductioninbodyweight,incomparisonwithsalinecontrols.

机译：Shigellosisisadiseaseofglobalproportions，withanestimated164.7millionepisodesannuallythroughouttheworldaswellasanestimated1.1millionassociatedmortalitiesindevelopingcountries.Duetoincreasingincidence，andcontinuedemergenceofmulti-drugresistantstrains，Shigellavaccinedevelopmentisconsideredatoppublichealthpriority.Theguineapigkeratoconjunctivitismodel，thebasisfortheSerenytest，remainsthemostreliableinvivoindicatorofvirulenceofShigellastrainsandimmunogenicityandprotectiveefficacyofShigellavaccinecandidates.ThemodeliseffectiveinevaluatingtheabilityofShigellastrainstoinvadethecornealepitheliaofguineapigsandspreadtocontiguouscells，withthemorevirulentstrainscausingulcerativekeratoconjunctivitis.However，analgesiaisnotroutinelyusedtorelievethispainfulconditionbecauseofpotentialimmunomodulationandconfoundingofexperimentalresults.TheobjectiveofthestudyreportedherewastoevaluateuseofbuprenorphinehydrochlorideasananalgesicduringtheSerenytest.Localandsystemicimmuneresponsesweremeasuredinguineapigsgivenb uprenorphineversusthoseresponsesincontrols.Resultsofthisstudysuggestthatbuprenorphine，administeredatananalgesicdoseof0.05mg / kgofbodyweighttwicedaily，canbesuccessfullyusedwiththemodelwithoutsignificantlyaffectingimmunologicevaluationofShigellavaccinecandidates.However，inbuprenorphine-treatedanimals，therewasasignificantincreaseintheamountofmucopurulentoculardischarge，requiringfrequentcleaningoftheaffectedeyes.Additionally，animalstreatedwithbuprenorphinehadsignificantreductioninbodyweight，incomparisonwithsalinecontrols。

著录项

来源
《Comparative Medicine》 |2001年第3期|共页
作者
Hanson Chris E.; Ruble Gaye R.; Essiet Idongesit; Hartman Antoinette B.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类畜牧、动物医学、狩猎、蚕、蜂;
关键词

相似文献

外文文献
中文文献
专利

1. Development of prophylactic recombinant HPV58-attenuated Shigella live vector vaccine and evaluation of its protective efficacy and immunogenicity in the guinea pig keratoconjunctivitis model [J] . Wensheng Li12 Hongli Liu3 Xiaofeng Yang2 Jin Zheng2 Yili Wang2 and Lusheng Si2* Acta Biochimica et Biophysica Sinica . 2009,第2期

机译：预防性重组HPV58减毒志贺氏菌活载体疫苗的开发及其在豚鼠角膜结膜炎模型中的保护效力和免疫原性的评估
2. Development of prophylactic recombinant HPV58-attenuated Shigeila live vector vaccine and evaluation of its protective efficacy and immunogenicity in the guinea pig keratoconjunctivitis model [J] . Wensheng Li, Hongli Liu, Xiaofeng Yang, 生物化学与生物物理学报：英文版 . 2009,第002期

机译：预防性重组HPV58减毒志贺拉活载体疫苗的开发及其在豚鼠角膜结膜炎模型中的保护效力和免疫原性评估
3. Construction of a Stable Attenuated Shigella sonnei ΔvirG Vaccine Strain, WRSS1, and Protective Efficacy and Immunogenicity in the Guinea Pig Keratoconjunctivitis Model [J] . Antoinette B. Hartman, Malabi M. Venkatesan Infection and immunity . 1998,第9期

机译：豚鼠角膜结膜炎模型中稳定减毒的痢疾志贺氏菌ΔvirG疫苗株，WRSS1的构建以及保护功效和免疫原性
4. Study on immunogenicity and protective efficacy of a new vaccine expressing Ag85B and MPT83 fusion protein from Mycobacterium tuberculosis [C] . Yufei Jin, Hong Bao, Jing Chang, International Conference on Human Health and Medical Engineering. . 2014

机译：从结核分枝杆菌中表达AG85B和MPT83融合蛋白的新疫苗免疫原性和保护效果的研究
5. A rhesus monkey model of respiratory syncytial virus (RSV) to evaluate the immunogenicity and protective efficacy of a DNA vaccine. [D] . Vaughan, Kerrie Colleen McArthur. 2002

机译：呼吸道合胞病毒（RSV）的恒河猴模型，用于评估DNA疫苗的免疫原性和保护功效。
6. Note: Construction of a Stable Attenuated Shigella sonnei ΔvirG Vaccine Strain WRSS1 and Protective Efficacy and Immunogenicity in the Guinea Pig Keratoconjunctivitis Model [O] . Antoinette B. Hartman, Malabi M. Venkatesan 1998

机译：注意：豚鼠角膜结膜炎模型中稳定减毒的痢疾志贺氏菌ΔvirG疫苗株WRSS1的构建以及保护功效和免疫原性
7. Multi-subunit BCG booster vaccine GamTBvac: Assessment of immunogenicity and protective efficacy in murine and guinea pig TB models. [O] . A P Tkachuk, V A Gushchin, V D Potapov, 2017

机译：多亚基BCG加强疫苗GamTBvac：评估小鼠和豚鼠TB模型的免疫原性和保护效力。
8. Species-Specific Surface Protein Antigen of Rickettsia typhi: Immunogenicity and Protective Efficacy in Guinea Pigs [R] . Bourgeois, A. L., Dasch, G. A. 1981

机译：伤寒立克次体的物种特异性表面蛋白抗原：豚鼠的免疫原性和保护效力

Effects of Buprenorphine on Immunogenicity and Protective Efficacy in the Guinea Pig Keratoconjunctivitis Model (Sereny Test)

摘要

著录项

相似文献

相关主题

期刊订阅