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首页> 外文期刊>Biology of Mood & Anxiety Disorders >Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans
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Altered amygdala activation during face processing in Iraqi and Afghanistani war veterans

机译：伊拉克和阿富汗退伍军人的面部加工过程中杏仁核的活化改变

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Background Exposure to combat can have a significant impact across a wide array of domains, and may manifest as post-traumatic stress disorder (PTSD), a debilitating mental illness that is associated with neural and affective sequelae. This study tested the hypothesis that combat-exposed individuals with and without PTSD, relative to healthy control subjects with no history of PTSD or combat exposure, would show amygdala hyperactivity during performance of a well-validated face processing task. We further hypothesized that differences in the prefrontal cortex would best differentiate the combat-exposed groups with and without PTSD. Methods Twelve men with PTSD related to combat in Operations Enduring Freedom and/or Iraqi Freedom, 12 male combat-exposed control patients with a history of Operations Enduring Freedom and/or Iraqi Freedom combat exposure but no history of PTSD, and 12 healthy control male patients with no history of combat exposure or PTSD completed a face-matching task during functional magnetic resonance imaging. Results The PTSD group showed greater amygdala activation to fearful versus happy faces than both the combat-exposed control and healthy control groups. Both the PTSD and the combat-exposed control groups showed greater amygdala activation to all faces versus shapes relative to the healthy control group. However, the combat-exposed control group relative to the PTSD group showed greater prefrontal/parietal connectivity with the amygdala, while the PTSD group showed greater connectivity with the subgenual cingulate. The strength of connectivity in the PTSD group was inversely related to avoidance scores. Conclusions These observations are consistent with the hypothesis that PTSD is associated with a deficiency in top-down modulation of amygdala activation by the prefrontal cortex and shows specific sensitivity to fearful faces.
机译：背景战斗暴露会在广泛的领域中产生重大影响，并且可能表现为创伤后应激障碍（PTSD），一种与神经和情感后遗症相关的衰弱性精神疾病。这项研究检验了以下假设：相对于没有PTSD或没有战斗史的健康对照受试者，有和没有PTSD的战斗暴露个体在执行经过充分验证的面部处理任务期间将显示杏仁核活动亢进。我们进一步假设前额叶皮层的差异将最好地区分有和没有PTSD的战斗暴露人群。方法12名与持久性自由作战和/或伊拉克自由作战有关的PTSD男性，12名具有持久性自由作战和/或伊拉克自由作战历史但没有PTSD经历的男性暴露于战斗中的对照患者和12名健康对照男性没有战斗暴露史或PTSD病史的患者在功能磁共振成像过程中完成了面部匹配任务。结果PTSD组显示，与战斗暴露对照组和健康对照组相比，恐惧和快乐面孔的杏仁核激活程度更高。相对于健康对照组，PTSD和暴露于战斗中的对照组均显示出更大的杏仁核对所有面部的激活和形状。但是，相对于PTSD组，暴露于战斗的对照组与杏仁核之间的前额叶/顶叶连接性更高，而PTSD组与下颚扣带的连接性更高。 PTSD组的连接强度与回避得分成反比。结论这些观察结果与PTSD与前额叶皮层对杏仁核激活的自上而下的调制不足有关并显示出对恐惧面孔的特殊敏感性的假说相符。

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