Effects of Impending Ovarian Failure Induced by 4-Vinylcyclohexene Diepoxide on Fertility in C57BL/6 Female Mice

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Effects of Impending Ovarian Failure Induced by 4-Vinylcyclohexene Diepoxide on Fertility in C57BL/6 Female Mice

机译：4-乙烯基环己烯二环氧化物诱发即将发生的卵巢衰竭对C57BL / 6雌性小鼠生育力的影响

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Repeateddailydosingofmicewith4-vinylcyclohexenediepoxide(VCD)causesagradualonsetofovarianfailure,providingamodelforperimenopause.Becauseincreasingnumbersofwomenaredelayingstartingafamily,infertilityinagingwomenisofconcern.ThisstudywasdesignedtodeterminetheeffectsofimpendingovarianfailureonfertilityinVCD-treatedmice.FemaleC57BL/6Jmiceweredoseddaily(17d)withvehiclecontrolorVCD(160mg/kg,intraperitoneally)todepleteprimordialfolliclesandthenweredividedinto2groups.Group1wasmatedsoonafterdosing;group2wasmatedonday20afterdosing,duringimpendingovarianfailure.Fertilitywasevaluatedongestationalday16.Ingroup1,cyclelength,pregnancyrate,andnumberoflivefetusesdidnotdifferbetweenVCD-treatedanimalsandcontrols,butVCD-treatedmicerequiredmorematingstobecomepregnantandhadmoreresorptions.Ingroup2,VCD-treatedmicedemonstratedproestrusandcopulatoryplugs,butonly1animalbecamepregnant,andshehadnoviablefetuses.Ovariesfrompregnantandnonpregnantcontrolscontainedsimilarnumbersoffolliclesandcorporalutea.OvariesfromVCD-treatedanimalscontainednofollicles,andcorporaluteawereseenonlyinpregnantanimals.InVCD-treatedmicematedsoonafterdosing,conceptionwasmoredifficultandmoreresorbedfetuseswereseen,whereasinthosematedclosertoimpendingovarianfailure,nosuccessfulpregnancieswereachieved.TheseresultsdemonstratethatVCD-treatedmicecanbeusedtomodelinfertilityinperimenopausalwomen.

机译：Repeateddailydosingofmicewith4-乙烯基环己烯（VCD）causesagradualonsetofovarianfailure，providingamodelforperimenopause.Becauseincreasingnumbersofwomenaredelayingstartingafamily，infertilityinagingwomenisofconcern.ThisstudywasdesignedtodeterminetheeffectsofimpendingovarianfailureonfertilityinVCD-treatedmice.FemaleC57BL / 6Jmiceweredoseddaily（17D）withvehiclecontrolorVCD（160mg / kg的，腹膜内）todepleteprimordialfolliclesandthenweredividedinto2groups.Group1wasmatedsoonafterdosing; group2wasmatedonday20afterdosing，duringimpendingovarianfailure.Fertilitywasevaluatedongestationalday16.Ingroup1，cyclelength，pregnancyrate，andnumberoflivefetusesdidnotdifferbetweenVCD-第2组中，用VCD处理的麦克风显示出了前驱和交配的栓塞，但只有1种动物被淹没了，并且她的胎儿具有新颖性。经处理的动物包含卵泡，而体腔动物只在怀孕的动物中使用。在用VCD处理的模仿剂量给药后不久，怀孕的观念变得更加困难，并且吸收了更多的胎儿，其中，由于即将发生的卵巢失败而被认为是正确的，因此无法通过成功的模范进行成功的研究。

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《Comparative Medicine》 |2007年第5期|共页
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Effects of Impending Ovarian Failure Induced by 4-Vinylcyclohexene Diepoxide on Fertility in C57BL/6 Female Mice

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