Noninvasive Assessment of Pulse-Wave Velocity and Flow-Mediated Vasodilation in Anesthetized G?ttingen Minipigs

Ludvigsen Trine P; Wiinberg Niels; Jensen Christina J; Callesen Annemette T; Andersen Regitze W; J?rgensen Anne Sofie H; Christoffersen Berit ?; Pedersen Henrik D; Moesgaard Sophia G; Olsen Lisbeth H

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Noninvasive Assessment of Pulse-Wave Velocity and Flow-Mediated Vasodilation in Anesthetized G?ttingen Minipigs

机译：麻醉的G？ttingen小型猪的脉搏波速度和流量介导的血管舒张的非侵入性评估

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Fewmethodsfornoninvasiveassessmentofarterialstiffnessandendothelialdysfunctioninporcinemodelsareavailable.TheaimofthisstudywastoevaluatemethodsforassessmentofarterialstiffnessandendothelialdysfunctioninanesthetizedG?ttingenminipigs.Pulse-wavevelocity(PWV)wasassessedinmaleG?ttingenminipigs(n=8;ageapproximately60wk)byusingapplanationtonometryofthecarotidandfemoralarteries.Inaddition,flow-mediatedvasodilation(FMD)wasassessedbyusingvascularultrasonographyofthebrachialarterytoevaluateendothelialdysfunction.Toevaluatethereproducibilityofthemethods,minipigswereanesthetizedbyintravenousinfusionofketamineandmidazolamandexaminedeveryotherdayforatotalof3trials.Neitherexaminationdaynorsystolic,diastolic,ormeanarterialbloodpressurestatisticallyinfluencedPWVorFMD.Themedianinterexaminationcoefficientofvariationwas17%forPWVand59%forFMD.MeasuredvaluesofPWVcorrespondedlargelytothoseinclinicallyhealthyhumans,butFMDvalueswerelowerthanexpectedforlean,younganimals.Althoughtheketamine#8211;midazolamanesthesiaweusedhasbeenassociatedwithminorhemodynamiceffectsinvivo,invitrostudiessuggestthatbothdrugsarevasodilatory.Thereforeanesthesiamighthaveinfluencedtheendothelialresponse,contributingtothemodestFMDresponseandtheconcurrenthighcoefficientsofvariationthatwenoted.WeconcludethatPWV#8212;butnotFMD#8212;showedacceptableinterexaminationvariationforitspotentialapplicationinporcinemodels.

机译：？Fewmethodsfornoninvasiveassessmentofarterialstiffnessandendothelialdysfunctioninporcinemodelsareavailable.TheaimofthisstudywastoevaluatemethodsforassessmentofarterialstiffnessandendothelialdysfunctioninanesthetizedG ttingenminipigs.Pulse-wavevelocity（PWV）wasassessedinmaleG ttingenminipigs（N = 8; ageapproximately60wk）？byusingapplanationtonometryofthecarotidandfemoralarteries.Inaddition，流-mediatedvasodilation（FMD）wasassessedbyusingvascularultrasonographyofthebrachialarterytoevaluateendothelialdysfunction.Toevaluatethereproducibilityofthemethods，minipigswereanesthetizedbyintravenousinfusionofketamineandmidazolamandexaminedeveryotherdayforatotalof3trials.Neitherexaminationdaynorsystolic，舒张压ormeanarterialbloodpressurestatisticallyinfluencedPWVorFMD.Themedianinterexaminationcoefficientofvariationwas17％forPWVand59％forFMD。 PWV的测量值在很大程度上对应于那些对健康有益的人类，但是FMD值比预期的瘦小动物要低。尽管氯胺酮＃8211;咪达唑烷由于绝种细菌具有与体内较小的血液动力学效应相关的作用，因此必须研究这两种药物均能使血管舒张。因此，该麻醉可能对内皮反应有影响，有助于研究应用FM 12的适度模型，并证实了存在的因果关系。

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《Comparative Medicine》 |2014年第6期|共页
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Ludvigsen Trine P; Wiinberg Niels; Jensen Christina J; Callesen Annemette T; Andersen Regitze W; J?rgensen Anne Sofie H; Christoffersen Berit ?; Pedersen Henrik D; Moesgaard Sophia G; Olsen Lisbeth H;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Noninvasive Assessment of Pulse-Wave Velocity and Flow-Mediated Vasodilation in Anesthetized Gottingen Minipigs [J] . Ludvigsen Trine P., Wiinberg Niels, Jensen Christina J., Comparative Medicine . 2014,第6期

机译：麻醉的哥廷根小型猪的脉搏波速度和流量介导的血管舒张的非侵入性评估
2. Noninvasive assessment of flow-mediated vasodilation with 30-MHz transducer in pregnant women (letter; comment) [J] . Yoshida A, Nakao S, Kobayashi H, Hypertension: An Official Journal of the American Heart Association . 1998,第5期

机译：用30 MHz换能器对孕妇进行血流介导的血管舒张的非侵入性评估（字母;评论）
3. Noninvasive Assessment of Flow-Mediated Vasodilation With 30-MHz Transducer in Pregnant Women [J] . Atsushi Yoshida, Shinji Nakao, Hisaaki Kobayashi, Hypertension: An Official Journal of the American Heart Association . 1998,第5期

机译：孕妇介导的30 MHz流量介导的血管舒张的非侵入性评估
4. Characterization of transcranial ultrasonic passage in the Göttingen minipig [C] . Mulgaonkar Amit P., Babakhanian Meghedi, Culjat Martin O., IEEE International Ultrasonics Symposium . 2014

机译：哥廷根小型猪的经颅超声通道特征
5. The impact of baseline artery diameter on human flow-mediated vasodilation: A comparison of brachial and radial artery responses to matched levels of shear stress. [D] . Jazuli, Farah. 2010

机译：基线动脉直径对人流介导的血管舒张的影响：肱动脉和radial动脉对相称水平的剪切应力反应的比较。
6. Noninvasive Assessment of Pulse-Wave Velocity and Flow-Mediated Vasodilation in Anesthetized Göttingen Minipigs [O] . Trine P Ludvigsen, Niels Wiinberg, Christina J Jensen, 2014

机译：麻醉的哥廷根小型猪的脉搏波速度和流量介导的血管舒张的非侵入性评估
7. A novel noninvasive and simple method for assessment of endothelial function: Enclosed zone flow-mediated vasodilation (ezFMD) using an oscillation amplitude measurement [O] . Idei Naomi, Ukawa Teiji, Kajikawa Masato, 2013

机译：一种新的无创且简单的评估内皮功能的方法：使用振荡幅度测量的封闭区域血流介导的血管舒张（ezFMD）

Noninvasive Assessment of Pulse-Wave Velocity and Flow-Mediated Vasodilation in Anesthetized G?ttingen Minipigs

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