Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage

An Daegi; Park Junyong; Shin Jong-Il; Kim Hyung-Joong; Jung Dong-In; Kang Ji-Houn; Kim Gonhyung; Chang Dong-Woo; Sur Jung-Hyang; Yang Mhan-Pyo; Lee Chulhyun; Kang Byeong-Teck

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Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage

机译：胶原酶诱导的脑出血狗的MRI特征的时空演变

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Intracerebralhemorrhage(ICH)isoneofthemostlethaltypesofstroke.Neuroimagingtechniques,particularlyMRI,haveimprovedthediagnosticaccuracyofICH.TheMRIcharacteristicsoftheevolvingstagesofICHinhumans#8212;butnotthoseindogs#8212;havebeendescribed.Inthisstudy,wedocumentthetemporalMRIcharacteristicsinacaninemodelofcollagenase-inducedICH.Specifically,ICHwasinducedin5healthybeaglesbyinjecting500UofbacterialcollagenasefromClostridiumhistolyticum,whichwasdeliveredintotheparietallobeover5minbyusingamicroinfusionpump.T1-andT2-weighted,fluid-attenuatedinversionrecovery,gradient-echo(GRE),anddiffusion-weighted(DWI)imagingandmeasurementoftheapparentdiffusioncoefficient(ADC)wereperformedseriallyat6differenttimepoints(beforeand12h,3d,5d,10dand24dafterhemorrhage)byusinga3-TMRsystem.ThetemporalchangesofT1signalintensity(SI)correspondedwellwiththereportedhumandata.ThetemporalchangesofT2andGREsequences,withtheexceptionofT2andGREhyperintensitiesattheearlysubacutestage,alsomatched.ADCmeasurementswerehighattheearlysubacutestage,andDWI-SIpositivelycorrelatedwithT2-andGRE-SIfromtheearlysubacutestageonward.Inconclusion,MRIisanidealmethodforcharacterizingthetemporalevolutionofparenchymalalterationsafterICHindogs.ThesedatamightbeusefulfordifferentiatingclinicalstagesofICHindogs.

机译：Intracerebralhemorrhage（ICH）isoneofthemostlethaltypesofstroke.Neuroimagingtechniques，particularlyMRI，haveimprovedthediagnosticaccuracyofICH.TheMRIcharacteristicsoftheevolvingstagesofICHinhumans＃8212; butnotthoseindogs＃8212; havebeendescribed.Inthisstudy，wedocumentthetemporalMRIcharacteristicsinacaninemodelofcollagenase-inducedICH.Specifically，ICHwasinducedin5healthybeaglesbyinjecting500UofbacterialcollagenasefromClostridiumhistolyticum，whichwasdeliveredintotheparietallobeover5minbyusingamicroinfusionpump.T1-andT2加权，流体attenuatedinversionrecovery，梯度回波（GRE），anddiffusion加权（DWI）imagingandmeasurementoftheapparentdiffusioncoefficient（ADC）wereperformedseriallyat6differenttimepoints（beforeand12h，3D，5D，10dand24dafterhemorrhage）byusinga3-TMRsystem.ThetemporalchangesofT1signalintensity（SI）correspondedwellwiththereportedhumandata.ThetemporalchangesofT2andGREsequences，withtheexceptionofT2andGREhyperintensitiesattheearlysubacutestage，alsomatched.ADCmeasurementswerehighattheea从亚急性阶段开始，亚急性阶段和DWI-SI与T2-和GRE-SI呈正相关。结论是，MRI是表征ICH犬后实质性异常旋转的理想方法。这些数据可能有助于区分ICH犬的临床阶段。

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《Comparative Medicine》 |2015年第6期|共页
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An Daegi; Park Junyong; Shin Jong-Il; Kim Hyung-Joong; Jung Dong-In; Kang Ji-Houn; Kim Gonhyung; Chang Dong-Woo; Sur Jung-Hyang; Yang Mhan-Pyo; Lee Chulhyun; Kang Byeong-Teck;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage [J] . An Daegi, Park Junyong, Shin Jong-Il, Comparative Medicine . 2015,第6期

机译：胶原酶诱导的脑出血狗的MRI特征的时空演变
2. Correlation of Diffusion MRI Findings with Lesion Progression in Patients with Traumatic Intracerebral Hemorrhage: Diffusion MRI in Traumatic Intracerebral Hemorrhages with Progression [J] . ErolF.S., DonmezO., AkgunB., Clinical neuroradiology. . 2014,第4期

机译：外伤性脑出血患者的弥散性MRI表现与病变进展的关系：外伤性脑出血患者的弥散性MRI表现与进展
3. Activation of PPAR-beta/delta Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model [J] . Neurochemical research . 2020,第4期

机译：通过抑制胶原酶诱导的脑内出血小鼠模型中的炎症和凋亡，激活PPAR-β/δ通过抑制炎症和凋亡来衰减脑损伤
4. An MRI-Compatible Robot for Intracerebral Hemorrhage Removal [C] . Yue Chen, Isuru S. Godage, Saikat Sengupta, Design of Medical Devices Conference . 2017

机译：用于脑内出血的MRI相容机器人去除
5. Bacterial collagenase-induced intracerebral hemorrhage in mouse: The role of matrix metalloproteinases and cell death mechanisms following injury. [D] . Grossetete, Mark Land. 2007

机译：小鼠细菌性胶原酶诱导的脑出血：损伤后基质金属蛋白酶的作用和细胞死亡机制。
6. Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage [O] . Daegi An, Junyong Park, Jong-Il Shin, 2015

机译：胶原酶诱导的脑出血狗的MRI特征的时间演变
7. Temporal MRI Assessment of Intracerebral Hemorrhage in Rats [O] . Donald M. Seyfried, Robert A. Knight, Yuxia Han, 2014

机译：大鼠脑出血的时间mRI评估

Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage

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