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首页> 外文期刊>Comparative and functional genomics >Identification and Comparative Analysis of the Peptidyl-Prolylcis/transIsomerase Repertoires ofH. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe
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Identification and Comparative Analysis of the Peptidyl-Prolylcis/transIsomerase Repertoires ofH. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe

机译：H的肽基-脯氨酰/反式异构酶库的鉴定和比较分析。智人，黑腹果蝇，秀丽隐杆线虫，酿酒酵母和Sz。庞贝

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The peptidyl-prolylcis/transisomerase (PPIase) class of proteins comprises threemember families that are found throughout nature and are present in all the majorcompartments of the cell. Their numbers appear to be linked to the number of genes intheir respective genomes, although we have found the human repertoire to be smallerthan expected due to a reduced cyclophilin repertoire. We show here that whilst themembers of the cyclophilin family (which are predominantly found in the nucleusand cytoplasm) and the parvulin family (which are predominantly nuclear) arelargely conserved between different repertoires, the FKBPs (which are predominantlyfound in the cytoplasm and endoplasmic reticulum) are not. It therefore appearsthat the cyclophilins and parvulins have evolved to perform conserved functions,while the FKBPs have evolved to fill ever-changing niches within the constantlyevolving organisms. Many orthologous subgroups within the different PPIase familiesappear to have evolved from a distinct common ancestor, whereas others, such as themitochondrial cyclophilins, appear to have evolved independently of one another. Wehave also identified a novel parvulin withinDrosophila melanogasterthat is unique tothe fruit fly, indicating a recent evolutionary emergence. Interestingly, the fission yeastrepertoire, which contains no unique cyclophilins and parvulins, shares no PPIasessolely with the budding yeast but it does share a majority with the higher eukaryotesin this study, unlike the budding yeast. It therefore appears that, in comparison withSchizosaccharomyces pombe, Saccharomyces cerevisiaeis a poor representation of thehigher eukaryotes for the study of PPIases.
机译：肽基脯氨酰顺式/反式异构酶（PPIase）类蛋白质包含三个成员家族，遍布整个自然界，并存在于细胞的所有主要部分中。它们的数量似乎与它们各自基因组中的基因数量有关，尽管我们发现由于亲环蛋白的种类减少，人类的种类比预期的要小。我们在这里显示，虽然亲环蛋白家族（主要存在于细胞核和细胞质中）和小白蛋白家族（主要存在于核蛋白）中的成员在不同库之间的保守性很高，但FKBP（主要存在于细胞质和内质网中）是保守的不。因此，看起来亲环蛋白和小病毒蛋白已经进化为执行保守功能，而FKBPs已经进化为填充不断发展的生物体内不断变化的壁ni。不同PPIase家族中的许多直系同源亚组似乎是从不同的共同祖先进化而来的，而其他诸如线粒体亲环蛋白的进化似乎彼此独立地进化了。我们还在果蝇中鉴定出一种新的小果蝇，它是果蝇所特有的，表明最近进化出现了。有趣的是，不包含独特的亲环蛋白和细小蛋白的裂变酵母库与萌芽酵母仅不共享PPIase，但与萌芽酵母不同，它确实与较高的真核生物共享大部分。因此，似乎与粟酒裂殖酵母相比，酿酒酵母在用于PPI酶研究的高等真核生物中表现不佳。

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