Decrease in Hepatic Drug-Metabolizing Enzyme Activities after Removal of Rats from Pine Bedding

Davey; Andrew Keith; nbsp; Fawcett; John Paul; nbsp; Lee; Soo Eng; nbsp; Chan; Kwok Kay; nbsp; Schofield; John C.

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Decrease in Hepatic Drug-Metabolizing Enzyme Activities after Removal of Rats from Pine Bedding

机译：大鼠从松床上褥中移出后，肝脏药物代谢酶活性的降低

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Woodisoftenusedasacontactbeddingmaterialforlaboratoryanimals.Ithasbeenestablishedthatwood,particularlysoftwood,hasthepotentialtoinducehepaticdrug-metabolizingenzymes.However,totheauthors'knowledge,changesinenzymeactivityafterremovalofanimalsfrombeddinghavenotbeencharacterized.Thepurposeofthestudyreportedherewastodeterminehowhepaticethoxyresorufin-O-deethylationandp-nitrophenolhydroxylationactivitiesalterovertimeafterremovalofratsfrompinebedding.Malerats,threetofourmonthsold,raisedincagescontainingpinebedding,weretransferredtowire-bottomedcages.Atvarioustimesthereafter(upto84days),groupsofratswereeuthanizedandtheliverwasprocessedtoobtainmicrosomes.ThemicrosomalproteinandtotalcytochromeP450(CYP)contentandenzymeactivitiesweredetermined.SignificantdifferencesintotalmicrosomalproteinortotalCYPvalueswerenotobservedoverthe84days,butadecreaseinethoxyresorufin-O-deethylationandp-nitrophenolhydroxylationactivitieswasdetected.Forp-nitrophenolhydroxylation,thedecreasewasexponential,withahalf-lifeofapproximatelyninedays,whereasforethoxyresorufin-O-deethylation,arapiddecreaseinactivityinthefirstweekwasfollowedbyareducedrateofdecreasethereafter.Enzymeactivitiesdidnotstabilizeforatleastsixweeks.Researchersusinglaboratoryanimalsshould,therefore,beawarethatittakesseveralweeksforenzymeactivitiestostabilizeonceanimalsareremovedfromthebedding.

机译：Woodisoftenusedasacontactbeddingmaterialforlaboratoryanimals.Ithasbeenestablishedthatwood，particularlysoftwood，hasthepotentialtoinducehepaticdrug-metabolizingenzymes.However，totheauthors'knowledge，changesinenzymeactivityafterremovalofanimalsfrombeddinghavenotbeencharacterized.Thepurposeofthestudyreportedherewastodeterminehowhepaticethoxyresorufin-O-deethylationandp-nitrophenolhydroxylationactivitiesalterovertimeafterremovalofratsfrompinebedding.Malerats，threetofourmonthsold，raisedincagescontainingpinebedding，weretransferredtowire-bottomedcages.Atvarioustimesthereafter（upto84days），groupsofratswereeuthanizedandtheliverwasprocessedtoobtainmicrosomes.ThemicrosomalproteinandtotalcytochromeP450（CYP）contentandenzymeactivitiesweredetermined.SignificantdifferencesintotalmicrosomalproteinortotalCYPvalueswerenotobservedoverthe84days ，检测到顺丁烯二酰氧基间苯二酚-O-脱乙基和对硝基苯酚羟基化活性。对硝基苯酚羟基化反应呈指数下降，具有半衰期大约在90天前，乙氧基间苯二酚-O-去乙基化后，第一个星期的活性迅速降低，其后降低了其降低率。酶活性至少连续六周未稳定下来。

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《Comparative Medicine》 |2003年第3期|共页
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Davey; Andrew Keith; nbsp; Fawcett; John Paul; nbsp; Lee; Soo Eng; nbsp; Chan; Kwok Kay; nbsp; Schofield; John C.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Decrease in hepatic drug-metabolizing enzyme activities after removal of rats from pine bedding [J] . Davey AK, Fawcett JP, Lee SE, Comparative Medicine . 2003,第3期

机译：从松床上褥中取出大鼠后，肝脏药物代谢酶活性的降低
2. Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11. [J] . Ueyama J, Kitaichi K, Nadai M, European Journal of Pharmacology: An International Journal . 2004,第1a3期

机译：吡格列酮对内毒素诱导的肝药物代谢酶活性以及CYP3A2和CYP2C11表达的影响。
3. Gram-Negative Endotoxin Administration Decreases Hepatic Drug-Metabolizing Enzymes during Development in Rats [J] . Babasaheb R Sonawane, Sumner J Yaffe Pediatric Research . 1980,第8期

机译：革兰氏阴性内毒素给药可降低大鼠发育过程中的肝药物代谢酶。
4. Structure-Activity Relationship and Substrate-Dependent Phenomena in Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes [C] . Miao Hao, Yuqing Zhao, Peizhan Chen, 第四届国际分子模拟与信息技术应用学术会议（The 4th International Conference of Molecular Simulations and Applied Informatics Technologies）论文集 . 2008

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5. Alterations in hepatic enzyme activity and progesterone clearance in lactating dairy cows. [D] . Lemley, Caleb Owens. 2010

机译：泌乳奶牛肝酶活性和孕酮清除率的变化。
6. Hepatic drug-metabolizing enzyme activity in rats pretreated with (−)-emetine or (±)-23-dehydroemetine [O] . H. H. Miller, R. K. Johnson, J. D. Donahue, 1970

机译：（-）-美美汀或（±）-23-脱氢美金汀预处理的大鼠肝药物代谢酶活性
7. Acute Peripheral Inflammation Increases Plasma Concentration of Hypoglycemic Agent Nateglinide with Decreased Hepatic Drug-Metabolizing Activity in Rats [O] . Moeko Kojina, Keiichiro Suzuki, Akane Nishiwaki, 2021

机译：急性外周炎症增加降血糖试剂等血浆浓度，其中大鼠的肝脏药物代谢活性降低
8. Differential Effects of Glucagon, Insulin and Epinephrine on In Vivo Glucose Oxidation and Hepatic Enzyme Activity in the Rat [R] . Klain, G. J., Herman, R. H. 1986

机译：胰高血糖素，胰岛素和肾上腺素对大鼠体内葡萄糖氧化和肝酶活性的影响

Decrease in Hepatic Drug-Metabolizing Enzyme Activities after Removal of Rats from Pine Bedding

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