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Leukocyte Mobilization Induced by Hypervolemia is Due to a Combined α- and -Adrenoceptor Activation

机译:高血容量引起的白细胞动员是由于结合的α-和-肾上腺素受体激活

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Aphenomenonofleukocytosisinducedbyhypervolemicstresswasdiscovered.Althoughasingleinjectionof350#59157;lofsaline(equivalenttoapprox.70mlinhumans,1ml/kgofbodyweight)didnothaveaneffectontheleukocytecountsinlong-termintravenouslycannulated,freelybehavingrats,asingleinjectionof750#59157;lofsaline(equivalenttoapprox.150mlinhumans,2.1ml/kg)inducedrapidleukocytosisof160%within1minutefollowedbyagradualincreaseupto180%after1hour.Measurementofserumnorepinephrineconcentrationrevealedasignificantincreaseinratsofthehypervolemicgroup,comparedwiththoseofthelowvolumegroup.Pretreatmentwitheitherthe#59137;-adrenoceptorantagonistnadololortheselectivesubxmlns="http://pub2web.metastore.ingenta.coms/"#945;2/sub-adrenoceptorantagonistyohimbinepreventedbothleukocytepeaksinthehighvolumegroup,suggestingacombinedreceptoractivation.Thiscriticaldependenceofleukocytecountsonchangesinbloodvolumeshouldbetakenintoconsiderationinexperimentswithlaboratoryanimals(thequantityofvolumeapplicationscanfalsifyresultsofexperiments).
机译:Aphenomenonofleukocytosisinducedbyhypervolemicstresswasdiscovered.Althoughasingleinjectionof350#59157; lofsaline(equivalenttoapprox.70mlinhumans,1毫升/ kgofbodyweight)didnothaveaneffectontheleukocytecountsinlong-termintravenouslycannulated,freelybehavingrats,asingleinjectionof750#59157; lofsaline(equivalenttoapprox.150mlinhumans,2.1毫升/ kg)的inducedrapidleukocytosisof160%within1minutefollowedbyagradualincreaseupto180%after1hour.Measurementofserumnorepinephrineconcentrationrevealedasignificantincreaseinratsofthehypervolemicgroup,comparedwiththoseofthelowvolumegroup.Pretreatmentwitheitherthe#59137 ; -adrenoceptorantagonistnadololortheselective #945; 2 -adrenoceptorantagonistyohimbine防止了白细胞在高容量组中出现,建议将其与受体结合起来进行定量分析(这是对这种可能性的重要考虑)。毛发)。

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