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首页> 外文期刊>Comparative Medicine >Histologic, Cytologic, and Bacteriologic Examinations of Experimentally Induced Salmonella typhimurium Infection in Lewis Rats
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Histologic, Cytologic, and Bacteriologic Examinations of Experimentally Induced Salmonella typhimurium Infection in Lewis Rats

机译：Lewis鼠鼠伤寒沙门氏菌感染的组织学，细胞学和细菌学检查

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BackgroundandPurpose:Histopathologicchanges,cellularcomposition,andbacterialspreadingwerestudiedinratspleenafterexperimentallyinducedinfectionwithSalmonellatyphimurium.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Lewisratswereinoculatedintraperitoneallywith106bacteria.Spleenweight,cellnumbers,andcellsurfacemarkerswerestudiedtogetherwithhistopathologicchanges,andexpressionofinduciblenitricoxidesynthase(iNOS).Thespreadofbacteriatoblood,spleen,liver,mesentericlymphnodes,lung,andkidneywasstudiedat12hours,and1,3,7,14,and28daysafterinoculation.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Experimentallyinducedinfectioncausedanincreaseinspleenweightandleukocytenumbers,andadecreaseinCD49d,onpostinoculationdays(PID)3through7.NumerousgranulomasweredisseminatedthroughoutthesplenicredpulpalsoonPID3through7.FromPID14on,clearanceofcellularexudateandregenerationoftissuestructurewereobserved.MassiveexpressionofiNOSwasseenonPID3.Bacterialgrowthwasobservedinliverandspleenfrom12hoursto14daysafterinoculation.BacteriaweredetectedinbloodonPID3andmesentericlymphnodeswereinfectedfromPID3through14.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Salmonellatyphimuriumwasrapidlytakenupbythereticuloendothelialsystem.Theinfectioninducedweightincreaseandreversiblechangesinthespleen,peakingonPID3withgranulomaformationandinfiltrationwithmacrophages.OnPID3,extensiveproductionofiNOSwithinthegranulomaswasobserved,suggestinginitialkillingofphagocytosedbacteria,followedbybacterialclearanceandtissueregeneration.CellsurfacemarkerexpressiononCD4+Tcellsindicatednochangeintheirnumbers;however,therewasatime-dependentchangeinexpressionofCD49d.
机译：BackgroundandPurpose：Histopathologicchanges，cellularcomposition，andbacterialspreadingwerestudiedinratspleenafterexperimentallyinducedinfectionwithSalmonellatyphimurium 方法：Lewisratswereinoculatedintraperitoneallywith106bacteria.Spleenweight，cellnumbers，andcellsurfacemarkerswerestudiedtogetherwithhistopathologicchanges，andexpressionofinduciblenitricoxidesynthase（iNOS）的.Thespreadofbacteriatoblood，脾接种后12小时，1、3、7、14和28天研究了肝脏，中肠淋巴结，肺和肾脏。 （PID）3到7。从PID3到7，在整个脾脏红浆中也消灭了许多肉芽肿。从PID 14开始，观察到细胞渗出液的清除和组织结构的再生。 dspleenfrom12hoursto14daysafterinoculation.BacteriaweredetectedinbloodonPID3andmesentericlymphnodeswereinfectedfromPID3through14 结论：Salmonellatyphimuriumwasrapidlytakenupbythereticuloendothelialsystem.Theinfectioninducedweightincreaseandreversiblechangesinthespleen，peakingonPID3withgranulomaformationandinfiltrationwithmacrophages.OnPID3，extensiveproductionofiNOSwithinthegranulomaswasobserved，suggestinginitialkillingofphagocytosedbacteria，followedbybacterialclearanceandtissueregeneration.CellsurfacemarkerexpressiononCD4 + Tcellsindicatednochangeintheirnumbers;然而，依赖于时间的CD49d变化表达。

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