...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biology Open >Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila
【24h】

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

机译：中心体丢失或扩增不会显着干扰果蝇中的整体基因表达

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to malignant transformation. One possibility is that centrosome defects might also perturb cellular homeostasis: for example, stress pathways are often activated in response to centrosome defects in cultured cells, and stress contributes to tumourigenesis in some fly models. Here we attempt to assess whether centrosome loss or centrosome amplification perturbs cell physiology in vivo by profiling the global transcriptome of Drosophila larval brains and imaginal discs that either lack centrosomes or have too many centrosomes. Surprisingly, we find that centrosome loss or amplification leads to few changes in the transcriptional profile of these cells, indicating that centrosome defects are surprisingly well tolerated by these cells. These observations indicate that centrosome defects can predispose fly brain cells to form tumours without, at least initially, dramatically altering their physiology.
机译：中心体缺陷是许多癌症的共同特征，它们可能使易飞的脑细胞形成肿瘤。在苍蝇中，中心体缺陷会扰乱神经干细胞的不对称分裂，但目前尚不清楚这可能如何导致恶性转化。一种可能性是，中心体缺陷也可能干扰细胞的动态平衡：例如，应激通路通常响应培养细胞中的中心体缺陷而被激活，并且在某些飞行模型中应激有助于肿瘤发生。在这里，我们试图通过分析果蝇幼虫大脑和缺少视点或中心点过多的假想椎间盘的整体转录组来评估中心体损失或中心体扩增是否干扰了体内的细胞生理。出人意料的是，我们发现中心体丢失或扩增导致这些细胞的转录谱变化很小，表明这些细胞出人意料地很好地耐受了中心体缺陷。这些观察表明，中心体缺陷可以使蝇脑细胞易于形成肿瘤，而至少在最初没有显着改变其生理学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号