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首页> 外文期刊>Biology Open >Activation of Drosophila hemocyte motility by the ecdysone hormone
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Activation of Drosophila hemocyte motility by the ecdysone hormone

机译：蜕皮激素可激活果蝇血细胞活力

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Drosophila hemocytes compose the cellular arm of the fly's innate immune system. Plasmatocytes, putative homologues to mammalian macrophages, represent ～95% of the migratory hemocyte population in circulation and are responsible for the phagocytosis of bacteria and apoptotic tissues that arise during metamorphosis. It is not known as to how hemocytes become activated from a sessile state in response to such infectious and developmental cues, although the hormone ecdysone has been suggested as the signal that shifts hemocyte behaviour from quiescent to migratory at metamorphosis. Here, we corroborate this hypothesis by showing the activation of hemocyte motility by ecdysone. We induce motile behaviour in larval hemocytes by culturing them with 20-hydroxyecdysone ex vivo . Moreover, we also determine that motile cell behaviour requires the ecdysone receptor complex and leads to asymmetrical redistribution of both actin and tubulin cytoskeleton.
机译：果蝇血细胞组成果蝇先天免疫系统的细胞臂。浆细胞是哺乳动物巨噬细胞的假定同源物，约占循环中移徙血细胞总数的95％，并负责变态过程中细菌和凋亡组织的吞噬作用。尽管已经提出激素蜕皮激素是在变形时将血细胞行为从静止转变为迁移的信号，但尚不清楚血细胞如何响应这种感染和发育线索而从静止状态激活。在这里，我们通过显示蜕皮激素对血细胞运动的激活来证实这一假设。我们通过与20-羟基蜕皮激素离体培养来诱导幼虫血细胞的运动行为。此外，我们还确定运动细胞的行为需要蜕皮激素受体复合物，并导致肌动蛋白和微管蛋白细胞骨架的不对称重新分布。

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