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首页> 外文期刊>Biology Open >Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands
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Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands

机译：果蝇Ror是Wnt配体的神经系统特异性共同受体

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Wnt ligands are secreted glycoproteins that control many developmental processes and are crucial for homeostasis of numerous tissues in the adult organism. Signal transduction of Wnts involves the binding of Wnts to receptor complexes at the surface of target cells. These receptor complexes are commonly formed between a member of the Frizzled family of seven-pass transmembrane proteins and a co-receptor, which is usually a single-pass transmembrane protein. Among these co-receptors are several with structural homology to receptor tyrosine kinases, including Ror, PTK7, Ryk and MUSK. In vertebrates, Ror-2 and PTK7 are important regulators of planar cell polarity (PCP). By contrast, PCP phenotypes were not reported for mutations inoff-track(otk) andoff-track2(otk2), encoding theDrosophilaorthologs of PTK7. Here we show thatDrosophilaRor is expressed in the nervous system and localizes to the plasma membrane of perikarya and neurites. A null allele ofRoris homozygous viable and fertile, does not display PCP phenotypes and interacts genetically with mutations inotkandotk2. We show that Ror binds specifically to Wingless (Wg), Wnt4 and Wnt5 and also to Frizzled2 (Fz2) and Otk. Our findings establishDrosophilaRor as a Wnt co-receptor expressed in the nervous system.
机译：Wnt配体是分泌的糖蛋白，可控制许多发育过程，并且对于成年生物中许多组织的体内平衡至关重要。 Wnts的信号转导涉及Wnts与靶细胞表面受体复合物的结合。这些受体复合物通常在七遍跨膜蛋白的卷曲蛋白家族的成员和通常为单遍跨膜蛋白的共受体之间形成。在这些共受体中，有几种与受体酪氨酸激酶具有结构同源性的受体，包括Ror，PTK7，Ryk和MUSK。在脊椎动物中，Ror-2和PTK7是平面细胞极性（PCP）的重要调节剂。相比之下，没有报道PCP表型在编码PTK7的果蝇直向同源物的脱轨（otk）和脱轨2（otk2）突变。在这里，我们显示果蝇Ror在神经系统中表达，并定位于周核膜和神经突的质膜。 Roris纯合的活等位基因的无效等位基因不显示PCP表型，并且与inotkandotk2突变发生遗传相互作用。我们显示Ror专门绑定到Wingless（Wg），Wnt4和Wnt5，还绑定到Frizzled2（Fz2）和Otk。我们的发现将果蝇Ror确立为在神经系统中表达的Wnt共同受体。

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