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Gastric Dilatation Syndrome Associated with Chronic Nephropathy, Hypergastrinemia, and Gastritis in Mice Exposed to High Levels of Environmental Antigens

机译:暴露于高水平环境抗原的小鼠的慢性肾脏病,高胃泌素血症和胃炎相关的胃扩张综合征

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Gastricdilatation(GD)hasbeenobservedinTac:(SW)fBRsurveillancemice,withmeanageof10months,thatareexposedtohighlevelsofenvironmentalantigensduringroutineexposuretodirtybedding.TheaimofthestudyreportedherewastodeterminewhetherGDwasassociatedwithothersystemicconditionsaffectingmice.Threegroupsofnineanimalsincluding#8212;surveillancemicenotexposedtodirtybedding(control),surveillancemicewithoutGD(NGD),andsurveillancemicewithGD(groupGD)#8212;hadmeanstomachweightwithingestaof0.5±0.02g,1.09±0.07g(P0.0001),and2.54±0.4g(P0.0001),respectively.MeanserumcreatinineconcentrationwassignificantlyhigherinGD(1.6±0.25mg/dl),comparedwithNGD(0.17±0.22mg/dl,P0.0001)andcontrol(0.2±0.16mg/dl,P0.0001)mice.Inaddition,lesionsconsistentwithseverechronicnephropathyandmildgastritiswerecommoninGD,comparedwithNGDandcontrolmice.Finally,serumamidatedgastrinconcentrationwassignificantlyhighinGD(179.37±53.86pM,P0.03)andNGD(264.89±115.89pM,P0.009),comparedwithcontrol(60.77±8.39pM)mice.Gastricdilatationsyndromeisassociatedwithchronicnephropathy,hypergastrinemia,andgastritisinsurveillancemiceexposedtohighlevelsofenvironmentalantigens.
机译:Gastricdilatation(GD)hasbeenobservedinTac:(SW)fBRsurveillancemice,withmeanageof10months,thatareexposedtohighlevelsofenvironmentalantigensduringroutineexposuretodirtybedding.TheaimofthestudyreportedherewastodeterminewhetherGDwasassociatedwithothersystemicconditionsaffectingmice.Threegroupsofnineanimalsincluding#8212; surveillancemicenotexposedtodirtybedding(对照),surveillancemicewithoutGD(NGD),andsurveillancemicewithGD(groupGD)#8212; hadmeanstomachweightwithingestaof0.5±0.02克,1.09±0.07克( P <0.0001)和2.54±0.4g(P <0.0001)。与NGD(0.17±0.22mg / dl,P <0.0001)和对照(0.2±0.16mg / dl)相比,GD中的肌酐浓度显着更高(1.6±0.25mg / dl)。 ,P <0.0001)小鼠。此外,与NGD和对照组相比,GD常见于重度慢性肾病和轻度胃炎。患有慢性肾病,高胃泌素血症和胃炎的监测小鼠均暴露于高水平的国防环境抗原中。

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