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首页> 外文期刊>Biology Open >An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity
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An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity

机译：一种用于研究超重力下鼠标运动和行为的仪器离心机

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摘要

Gravity may influence multiple aspects of legged locomotion, from the periods of limbs moving as pendulums to the muscle forces required to support the body. We present a system for exposing mice to hypergravity using a centrifuge and studying their locomotion and activity during exposure. Centrifuge-induced hypergravity has the advantages that it both allows animals to move freely, and it affects both body and limbs. The centrifuge can impose two levels of hypergravity concurrently, using two sets of arms of different lengths, each carrying a mouse cage outfitted with a force and speed measuring exercise wheel and an infrared high-speed camera; both triggered automatically when a mouse begins running on the wheel. Welfare is monitored using infrared cameras. As well as detailing the design of the centrifuge and instrumentation, we present example data from mice exposed to multiple levels of hypergravity and details of how they acclimatized to hypergravity.
机译：重力可能影响腿部运动的多个方面，从四肢摆动的时期到支撑身体所需的肌肉力量。我们提出了一种使用离心机将小鼠暴露于超重力环境并研究其在运动过程中的运动和活动的系统。离心机引起的超重力的优点是，它既可以使动物自由活动，又可以影响身体和四肢。离心机可以使用两组不同长度的臂同时施加两个级别的超重力，每个臂带有一个装有力和速度测量健身轮以及红外高速摄像头的鼠标笼。当鼠标开始在滚轮上运行时，两者都会自动触发。使用红外热像仪监控福利。除了详细介绍离心机和仪器的设计外，我们还提供了来自暴露于多种超重力水平的小鼠的示例数据，以及它们如何适应超重力的详细信息。

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