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首页> 外文期刊>Comparative and functional genomics >Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems
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Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems

机译：轮班工作介导的昼夜节律紊乱和睡眠稳态引起严重的健康问题

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摘要

Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.
机译：在近几十年来，随着人类生活需求的增长，轮班工作变得很普遍。尽管没有社交活动和习惯上的不规律，但连续不断的不规则轮班仍会导致严重的健康问题，包括睡眠障碍，精神病，癌症和代谢障碍。这些健康问题是由于生物钟系统的破坏而引起的，这与基因表达的改变有关。时钟控制基因的改变进一步影响与包括重度抑郁症，双相情感障碍，相延迟和相提前睡眠综合征，乳腺癌和结肠癌在内的疾病相关的基因。需要进行各种各样的研究工作，以研究大脑和神经系统中时差引起的广谱变化。这篇综述旨在激发研究人员在该领域进行深入研究，以识别风险因素和机制。它的目标扩展到使轮班工人意识到与轮班相关的风险。

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