Kinetic Profile of Influenza Virus Infection in Three Rat Strains

Daniels; Mary J.; nbsp; Selgrade; MaryJane K.; nbsp; Doerfler; Donald; nbsp; Gilmour; M. Ian

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Kinetic Profile of Influenza Virus Infection in Three Rat Strains

机译：三种大鼠品系中流感病毒感染的动力学特征

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Influenzaisarespiratorytractdiseaseofviraloriginthatcancausemajorepidemicsinhumans.Theinfluenzavirusinfectsanddamagesepithelialcellsoftherespiratorytractandcausespneumonia.Lunglesionsofmiceinfectedwithinfluenzavirusresemblesthoseseeninhumanswithinfluenza,andcanresultinsevereandevenfatalpneumonia.Incontrast,experimentalinfectionofratswiththevirusinducesamilderformofthedisease,withnomortality.ThepurposeofthestudyreportedherewastodeterminethetimecourseofinfluenzainfectionandlunginjuryinBrownNorway(BN),Fischer-344(F344),andSprague-Dawley(SD)ratstoascertainwhethergeneticbackgroundimpactssusceptibilitytoinfectionandhostresponses.Ratsofeachstrainwereinoculatedintranasallywith10,000plaque-formingunitsofrat-adaptedinfluenzavirus(RAIV),andlungswereassessedatpostinoculationhour(PIH)2,24,48,72,and144forviraltiter,inflammatorycells,pro-inflammatorycytokines,andbiochemicalindicatorsoflungedema(protein)andinjury(lactatedehydrogenase[LD]activity).VirustiterpeakedatPIH24,andwas100-foldhigherintheF344andSD,comparedwiththeBNstrain.Alveolarmacrophages,LDactivity,andtotalproteinconcentrationwerehigherintheBNrats,whereasneutrophilnumbersandinterleukin6andtumornecrosisfactor-alphaactivitiesweregreatestinthebronchoalveolarlavagefluidofF344andSDrats.TheresultsindicatethatF344andSDratsrespondinsimilarmannertoviralinfection,whereasviralreplicationwasmorelimitedinBNratsandwasassociatedwithadifferentprofileofpulmonarycells.

机译：Influenzaisarespiratorytractdiseaseofviraloriginthatcancausemajorepidemicsinhumans.Theinfluenzavirusinfectsanddamagesepithelialcellsoftherespiratorytractandcausespneumonia.Lunglesionsofmiceinfectedwithinfluenzavirusresemblesthoseseeninhumanswithinfluenza，andcanresultinsevereandevenfatalpneumonia.Incontrast，experimentalinfectionofratswiththevirusinducesamilderformofthedisease，withnomortality.ThepurposeofthestudyreportedherewastodeterminethetimecourseofinfluenzainfectionandlunginjuryinBrownNorway（BN），费 - 344（F344），andSprague - 道（SD）ratstoascertainwhethergeneticbackgroundimpactssusceptibilitytoinfectionandhostresponses.Ratsofeachstrainwereinoculatedintranasallywith10,000plaque-formingunitsofrat-adaptedinfluenzavirus（RAIV），andlungswereassessedatpostinoculationhour（PIH）2 ，24、48、72和144分别代表PIH24的病毒滴度和较高的100倍，用于病毒，炎性细胞，促炎性细胞因子和生化指标，说明月球菌（蛋白质）和损伤（乳酸脱氢酶[LD]活性）。 DSD，comparedwiththeBNstrain.Alveolarmacrophages，LDactivity，andtotalproteinconcentrationwerehigherintheBNrats，whereasneutrophilnumbersandinterleukin6andtumornecrosisfactor-alphaactivitiesweregreatestinthebronchoalveolarlavagefluidofF344andSDrats.TheresultsindicatethatF344andSDratsrespondinsimilarmannertoviralinfection，whereasviralreplicationwasmorelimitedinBNratsandwasassociatedwithadifferentprofileofpulmonarycells。

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《Comparative Medicine》 |2003年第3期|共页
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Daniels; Mary J.; nbsp; Selgrade; MaryJane K.; nbsp; Doerfler; Donald; nbsp; Gilmour; M. Ian;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Kinetic profile of influenza virus infection in three rat strains [J] . Daniels MJ, Selgrade MK, Doerfler D, Comparative Medicine . 2003,第3期

机译：三种大鼠品系中流感病毒感染的动力学特征
2. Cytokine Profiles in the Respiratory Tract During Primary Infection With Human Metapneumovirus, Respiratory Syncytial Virus, or Influenza Virus in Infants [J] . A. Clara Monsalvo, Federico R. Laham, Fernando P. Polack, Pediatrics: Official Publication of the American Academy of Pediatrics . 2007,第2期

机译：婴儿初次感染人类偏肺病毒，呼吸道合胞病毒或流感病毒期间呼吸道中的细胞因子谱
3. Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens [J] . Yan Dan, Weisshaar Marco, Lamb Kristen, Biochemistry . 2015,第36期

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4. Strain-Specific Immune Response to Influenza Virus Infection [C] . Emily E. Ackerman, Ericka Mochan, Jason E. Shoemaker IFAC Conference on Foundations of Systems Biology in Engineering . 2020

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5. VARIATIONS IN THE PATHOGENESIS OF WATERFOWL INFLUENZA VIRUS INFECTIONS: ENTERIC INFECTIONS IN DUCKS, RESPIRATORY INFECTIONS IN TURKEYS AND NEPHROSIS IN CHICKENS [D] . SLEMONS, RICHARD DEAN 1981

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6. Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections [O] . Yung-Chieh Tseng, Chia-Yu Wu, Ming-Liang Liu, 2019

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7. Influenza virus infection of newborn rats: virulence of recombinant strains prepared from influenza virus strain A/Okuda/57 [O] . C. TEH, R. JENNINGS, C. W. POTTER 1980

机译：新生大鼠的流感病毒感染：由流感病毒菌株制备的重组菌株的毒力A / Okuda / 57

Kinetic Profile of Influenza Virus Infection in Three Rat Strains

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