Lymphocyte Subsets in Neonatal and Juvenile Cats: Comparison of Blood and Lymphoid Tissues

Bortnick Sandra J.; Orandle Marlene S.; Papadi George P.; Johnson Calvin M.

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Lymphocyte Subsets in Neonatal and Juvenile Cats: Comparison of Blood and Lymphoid Tissues

机译：新生和幼猫中的淋巴细胞亚群：血液和淋巴组织的比较

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Objective:Tocomparelymphocytesubpopulationsinthebloodandlymphoidtissuesofnormalkittensbetween1and90daysofage.Methods:Lymphocytesubsetswithintheblood,thymus,andlymphnodeof24normalkittenswerequantifiedbyuseoftwo-colorfluorescenceflowcytometryandwerecomparedat1,23,46,or90daysafterbirth.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:BloodBandTlymphocytesincreasedoverthe90-daypostnatalperiod.TheCD4+andCD8+subpopulationsofTlymphocytesincreased.However,CD8+lymphocytesincreasedmorethandidCD4+lymphocytes,resultinginreducedCD4-to-CD8ratio.By23daysofage,similarbutmoreabruptchangesintheCD4to-CD8ratiooccurredinthethymusandlymphnodes,coincidingwiththehighestthymus-to-bodyweightratioandgradualincreaseinmaturethymocytesexpressingapan-Tlymphocytemarker.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:PostnatalthymopoiesisinthedomesticcatfavorsproductionofmatureCD8+TlymphocytesoverCD4+Tlymphocytes.ThiscoincideswiththeemergenceofCD8+lymphocytesinthelymphnodeandprecedesamoregradualincreaseinCD8+cellsintheblood.Therefore,theontogenyoftheseeffectorsofcellmediatedimmunitycouldbeinterruptedbyinfectiveagentsthattargetlymphoidtissuesoftheneonate.

机译：目的：Tocomparelymphocytesubpopulationsinthebloodandlymphoidtissuesofnormalkittensbetween1and90daysofage.Methods：Lymphocytesubsetswithintheblood，胸腺，andlymphnodeof24normalkittenswerequantifiedbyuseoftwo-colorfluorescenceflowcytometryandwerecomparedat1,23,46，or90daysafterbirth 结果：BloodBandTlymphocytesincreasedoverthe90-daypostnatalperiod。 TheCD4 + andCD8 + subpopulationsofTlymphocytesincreased.However，CD8 + lymphocytesincreasedmorethandidCD4 +淋巴细胞，resultinginreducedCD4到CD8ratio.By23daysofage，similarbutmoreabruptchangesintheCD4to-CD8ratiooccurredinthethymusandlymphnodes，coincidingwiththehighestthymus到bodyweightratioandgradualincreaseinmaturethymocytesexpressingapan-Tlymphocytemarker。结论：产后胸腺生成是家猫有利于CD4 +淋巴细胞生成的CD8 +淋巴细胞的成熟。这与淋巴结中CD8 +淋巴细胞的出现并优先因此，血液中CD8 +细胞的数量会逐渐增加。因此，靶向淋巴组织软变种的感染剂可能会中断细胞介导的免疫功能的产生。

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《Comparative Medicine》 |1999年第4期|共页
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Bortnick Sandra J.; Orandle Marlene S.; Papadi George P.; Johnson Calvin M.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Lymphocyte subsets in neonatal and juvenile cats: comparison of blood and lymphoid tissues [J] . Bortnick SJ, Orandle MS, Papadi GP, Laboratory Animal Science . 1999,第4期

机译：新生和幼年猫的淋巴细胞亚群：血液和淋巴组织的比较
2. Isolation and purification of lymphocyte subsets from gut-associated lymphoid tissue in neonatal swine. [J] . Solano Aguilar-GI, Vengroski KG, Beshah E, Journal of Immunological Methods . 2000,第1a2期

机译：新生猪肠道相关淋巴组织淋巴细胞亚群的分离和纯化。
3. The normalization of guinea pig leukocyte fractions and lymphocyte subsets in blood and lymphoid tissues using a flow cytometric procedure [J] . Takizawa M, Chiba J, Haga S, Experimental Animals . 2004,第4期

机译：使用流式细胞仪对豚鼠白血球成分和血液及淋巴组织中的淋巴细胞亚群进行标准化
4. Correlation between changes in lymphocyte subsets in blood and peripheral lymphoid tissues in pigs infected experimentally with a European field strain of Porcine Reproductive and Respiratory Syndrome [C] . Gomez-Laguna J, Salguero FJ, Pallares FJ, Congress of the International Pig Veterinary Society . 2008

机译：用欧洲野生猪生殖和呼吸综合征在实验感染血液和外周淋巴组织中淋巴细胞亚群的相关性
5. Investigating the role of Ly-6A/Sca-1 in editing of antigen receptor (BCR) on B lymphocytes in the Gut Associated Lymphoid Tissues (GALT). [D] . Spencer, Stacey. 2013

机译：研究Ly-6A / Sca-1在肠相关淋巴组织（GALT）B淋巴细胞抗原受体（BCR）编辑中的作用。
6. Cyclophosphamide-induced eosinophilia in the rat: concomitant changes in T-cell subsets B cells and large granular lymphocytes within lymphoid tissues. [O] . A W Thomson, I H Mathie, H F Sewell 1987

机译：大鼠环磷酰胺诱发的嗜酸性粒细胞增多：淋巴组织内的T细胞亚群B细胞和大颗粒淋巴细胞伴随变化。
7. Cover Picture: The cover image features a frozen section from an embryonic day 16 mouse spleen stained by immunofluorescence to demonstrate the presence and location of lymphoid tissue inducer (LTi) cells. Witherset al. (pp. 3240–3245) show that these cells form the focus of lymphocyte accumulation in the developing mouse spleen. Red staining for CD45 marks haemopoietic cells, green shows IL-7Rα expression, and CD4 expression is in blue. LTi cells that express all markers (in white) cluster around blood vessels in the embryonic spleen where signalling to stromal cells initiates lymphocyte recruitment. – Eur. J. Immunol. 11/2007 [O] . David R. Withers, Mi-Yeon Kim, Vasileios Bekiaris, 2007

机译：封面图片：盖子图像具有来自免疫荧光染色的胚胎第16天小鼠脾脏的冷冻部分，以证明淋巴组织诱导症（LTI）细胞的存在和位置。靠近al。（第3240-3245页）表明，这些细胞在培养的小鼠脾脏中形成了淋巴细胞积累的焦点。 CD45的红色染色标记血液成对细胞，绿色显示IL-7Rα表达，CD4表达是蓝色的。 LTI细胞，其在胚胎脾脏周围表达血管周围的所有标记（白色）簇，其中信号传导到基质细胞引发淋巴细胞募集。 - 欧元。 J.Immunol。 11/2007
8. Genetic Requirements for Mixed Lymphocyte Culture Response of Peripheral Blood Lymphocytes of Mice Depleted of Alloantigen-Reactive Lymphoid Cells. [R] . Ryan, J. J., Ahmed, A., Sell, K. W. 1977

机译：异体抗原 - 反应性淋巴细胞耗竭小鼠外周血淋巴细胞混合淋巴细胞培养反应的遗传要求。

Lymphocyte Subsets in Neonatal and Juvenile Cats: Comparison of Blood and Lymphoid Tissues

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