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首页> 外文期刊>Comparative Medicine >B-Virus Specific-Pathogen-Free Breeding Colonies of Macaques (Macaca mulatta): Retrospective Study of Seven Years of Testing
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B-Virus Specific-Pathogen-Free Breeding Colonies of Macaques (Macaca mulatta): Retrospective Study of Seven Years of Testing

机译：猕猴（猕猴）B病毒无特定病原体繁殖的殖民地：七年测试的回顾性研究。

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BackgroundandPurpose:NationalInstitutesofHealth'sDivisionofComparativeMedicinehassponsoredamulti-institutionalprogramfortheestablishmentofspecific-pathogen-free(SPF)macaquecolonies.Bvirus(Herpesvirussimiae,Cercopithecineherpesvirustype1)hasbeentargetedinthissurveillance.Participatinginstitutionshaveestablishedindividualtimetablesforfrequencyoftestingandtypesofmonitoringandhusbandrytechniques,allwiththecommongoalofproducingpathogen-freemonkeysforresearch.Thegreatestbiosecuritythreattotheprogramcomesfromfailuretodetectseronegativelatentinfections,eitherinfirst-yearmacaquesormacaquesintroducedinsubsequentyears,althoughthesearesupposedtooperateasclosedcolonies.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:FromJanuary1990throughDecember1996,wescreenedmacaquesforBvirus,usingenzyme-linkedimmunoabsorbantassay(ELISA)andWesternblotanalysis.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Duringthefirstyear,1,097macaquesfromsixcoloniesweretested,and88.4%testednegativeforBvirus.Duringtheseventhyear,1,843weretested,ofwhich99.7%testednegative.Seropositivemacaquesweredetectedaslateastheseventhyear.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:AnaggressiveprogramtoestablishanSPFcolonyofcaptivebreedingmacaquescanbeeffectiveinreducingtheriskofB-virusexposure.
机译：BackgroundandPurpose：NationalInstitutesofHealth'sDivisionofComparativeMedicinehassponsoredamulti-institutionalprogramfortheestablishmentofspecific无病原体（SPF）macaquecolonies.Bvirus（Herpesvirussimiae，Cercopithecineherpesvirustype1）hasbeentargetedinthissurveillance.Participatinginstitutionshaveestablishedindividualtimetablesforfrequencyoftestingandtypesofmonitoringandhusbandrytechniques，allwiththecommongoalofproducingpathogen-freemonkeysforresearch.Thegreatestbiosecuritythreattotheprogramcomesfromfailuretodetectseronegativelatentinfections，eitherinfirst-yearmacaquesormacaquesintroducedinsubsequentyears，althoughthesearesupposedtooperateasclosedcolonies 方法：从1990年1月至1996年12月，使用酶联免疫吸附法（Westernblotanalysis）和酶联免疫吸附法（Westernblotanalysis）筛选了用于B病毒的猕猴。结果：在第一年中，对六个殖民地的1097只猕猴进行了测试，其中88.4％进行了测试在第7年中，测试了1,843个，其中99.7％被测试为阴性。直到第7年为止，都检测到了血清阳性的猕猴。

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