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Auditory Brainstem Responses in Golden Syrian Hamsters (Mesocricetus auratus) Affected with the Wh Gene

机译:Wh基因影响的金色叙利亚仓鼠(金龟)的听觉脑干反应。

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BackgroundandPurpose:Theanophthalmicwhite(Wh)geneinGoldenSyrianhamsters(Mesocricetusauratus)isautosomalsemi-dominantandcausesseveraldevelopmentaldefects,includinghearingloss.TheWhmutationisthoughttobehomologoustoWaardenburgsyndromeinhumans,apparentlyaffectingsimilardevelopmentalprocesses.ThepurposeofthisstudywastoassessthehearingofhamstersintheAN/As-Whstrain.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Usingauditorybrainstemresponses,electrophysiologicactivitywasdeterminedin20hamstersoftheAN/As-Whstrain,withtheaimofelucidatinghearingstatus.Hamsterswereclassifiedintofivegenotypesandwereevaluatedbyuseofclickstimuli.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResultsandConclusion:Hamstersassignedtothegenotypesdifferedintheirhearingsensitivityandcouldbeclassifiedintocategoriesofnormalhearing,moderatehearingloss,andprofoundhearingloss.
机译:BackgroundandPurpose:Theanophthalmicwhite(WH)geneinGoldenSyrianhamsters(Mesocricetusauratus)isautosomalsemi-dominantandcausesseveraldevelopmentaldefects,includinghearingloss.TheWhmutationisthoughttobehomologoustoWaardenburgsyndromeinhumans,apparentlyaffectingsimilardevelopmentalprocesses.ThepurposeofthisstudywastoassessthehearingofhamstersintheAN / AS-Whstrain 方法:Usingauditorybrainstemresponses,electrophysiologicactivitywasdeterminedin20hamstersoftheAN / AS-Whstrain,withtheaimofelucidatinghearingstatus.Hamsterswereclassifiedintofivegenotypesandwereevaluatedbyuseofclickstimuli ResultsandConclusion:Hamstersassignedtothegenotypesdifferedintheirhearingsensitivityandcouldbeclassifiedintocategoriesofnormalhearing,moderatehearingloss,andprofoundhearingloss。

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