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首页> 外文期刊>Comparative and functional genomics >Comparative Genome Sequence Analysis Reveals the Extent of Diversity and Conservation for Glycan-Associated Proteins inBurkholderiaspp.
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Comparative Genome Sequence Analysis Reveals the Extent of Diversity and Conservation for Glycan-Associated Proteins inBurkholderiaspp.

机译：比较基因组序列分析揭示了伯克霍尔德氏菌中糖相关蛋白的多样性和保守性。

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摘要

Members of theBurkholderiafamily occupy diverse ecological niches. In pathogenic family members, glycan-associated proteins are often linked to functions that include virulence, protein conformation maintenance, surface recognition, cell adhesion, and immune system evasion. Comparative analysis of availableBurkholderiagenomes has revealed a core set of 178 glycan-associated proteins shared by allBurkholderiaof which 68 are homologous to known essential genes. The genome sequence comparisons revealed insights into species-specific gene acquisitions through gene transfers, identified an S-layer protein, and proposed that significantly reactive surface proteins are associated to sugar moieties as a potential means to circumvent host defense mechanisms. The comparative analysis using a curated database of search queries enabled us to gain insights into the extent of conservation and diversity, as well as the possible virulence-associated roles of glycan-associated proteins in members of theBurkholderiaspp. The curated list of glycan-associated proteins used can also be directed to screen other genomes for glycan-associated homologs.
机译：伯克霍尔德氏家族的成员占据着各种各样的生态位。在致病性家族成员中，与聚糖相关的蛋白质通常与包括毒力，蛋白质构象维持，表面识别，细胞粘附和免疫系统逃避的功能相关。对可用伯克霍尔德氏菌基因组的比较分析显示，所有伯克霍尔德氏菌共有178种与聚糖相关的蛋白质，其中68种与已知必需基因同源。基因组序列比较揭示了通过基因转移获得物种特异性基因的见解，鉴定了S层蛋白，并提出了具有显着反应性的表面蛋白与糖部分相关，是规避宿主防御机制的潜在手段。使用精选的搜索查询数据库进行的比较分析使我们能够深入了解保护和多样性的程度，以及与伯克霍尔德氏菌成员中聚糖相关蛋白的可能的毒力相关作用。所使用的与聚糖相关的蛋白质的精选清单也可以针对与聚糖相关的同源物筛选其他基因组。

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