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Screen for Footprints of Selection during Domestication/Captive Breeding of Atlantic Salmon

机译：大西洋鲑的驯化/圈养繁殖过程中选择足迹的筛选

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Domesticated animals provide a unique opportunity to identify genomic targets of artificial selection to the captive environment. Here, we screened three independent domesticated/captive Atlantic salmon (Salmo salar) strains and their wild progenitor populations in an effort to detect potential signals of domestication selection by typing of 261 SNPs and 70 microsatellite loci. By combining information from four different neutrality tests, in total ten genomic regions showed signs of directional selection based on multiple sources of evidence. Most of the identified candidate regions were rather small ranging from zero to a few centimorgans (cM) in the female Atlantic salmon linkage map. We also evaluated how adaptation from standing variation affects adjacent SNP and microsatellite variation along the chromosomes and, by using forward simulations with strong selection, we were able to generate genetic differentiation patterns comparable to the observed data. This study highlights the significance of standing genetic variation during the early stages of adaptation and represents a useful step towards identifying functional variants involved in domestication of Atlantic salmon.
机译：驯养的动物提供了一个独特的机会来识别人工选择对圈养环境的基因组目标。在这里，我们筛选了三种独立的驯化/圈养大西洋鲑（Salmo salar）菌株及其野生祖细胞，以通过键入261个SNP和70个微卫星基因座来检测驯化选择的潜在信号。通过结合来自四个不同中立性测试的信息，总共十个基因组区域显示出基于多种证据来源进行方向选择的迹象。在女性大西洋鲑鱼连锁图中，大多数已确定的候选区域很小，范围从零到几个厘摩（cM）。我们还评估了来自站立变异的适应如何影响沿染色体的相邻SNP和微卫星变异，并且通过使用具有强选择力的正向模拟，我们能够产生与观察到的数据相当的遗传分化模式。这项研究突出了适应早期阶段站立遗传变异的重要性，并代表了确定大西洋鲑驯化所涉及的功能变异的有用步骤。

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