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The eIF4F and eIFiso4F Complexes of Plants: An Evolutionary Perspective

机译：植物的eIF4F和eIFiso4F复合体：进化的角度。

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Translation initiation in eukaryotes requires a number of initiation factors to recruit the assembled ribosome to mRNA. The eIF4F complex plays a key role in initiation and is a common target point for regulation of protein synthesis. Most work on the translation machinery of plants to date has focused on flowering plants, which have both the eIF4F complex (eIF4E and eIF4G) as well as the plant-specific eIFiso4F complex (eIFiso4E and eIFiso4G). The increasing availability of plant genome sequence data has made it possible to trace the evolutionary history of these two complexes in plants, leading to several interesting discoveries. eIFiso4G is conserved throughout plants, while eIFiso4E only appears with the evolution of flowering plants. The eIF4G N-terminus, which has been difficult to annotate, appears to be well conserved throughout the plant lineage and contains two motifs of unknown function. Comparison of eIFiso4G and eIF4G sequence data suggests conserved features unique to eIFiso4G and eIF4G proteins. These findings have answered some questions about the evolutionary history of the two eIF4F complexes of plants, while raising new ones.
机译：真核生物的翻译起始需要许多起始因子才能将组装好的核糖体募集到mRNA。 eIF4F复合物在启动中起关键作用，并且是调节蛋白质合成的共同目标。迄今为止，有关植物翻译机制的大多数工作都集中在开花植物上，开花植物既具有eIF4F复合体（eIF4E和eIF4G）又具有植物特异性eIFiso4F复合体（eIFiso4E和eIFiso4G）。植物基因组序列数据可用性的提高使得追踪这两种复合物在植物中的进化历史成为可能，从而导致了一些有趣的发现。 eIFiso4G在整个植物中都是保守的，而eIFiso4E仅随着开花植物的进化而出现。难以注释的eIF4G N末端似乎在整个植物谱系中都保存良好，并包含两个功能未知的基序。 eIFiso4G和eIF4G序列数据的比较表明，eIFiso4G和eIF4G蛋白具有独特的保守特征。这些发现回答了关于两种植物eIF4F复合体进化史的一些问题，同时又提出了新的问题。

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