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首页> 外文期刊>Comparative and functional genomics >The Coevolution of Phycobilisomes: Molecular Structure Adapting to Functional Evolution
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The Coevolution of Phycobilisomes: Molecular Structure Adapting to Functional Evolution

机译：藻胆体的协同进化：分子结构适应功能进化

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Phycobilisome is the major light-harvesting complex in cyanobacteria and red alga. It consists of phycobiliproteins and their associated linker peptides which play key role in absorption and unidirectional transfer of light energy and the stability of the whole complex system, respectively. Former researches on the evolution among PBPs and linker peptides had mainly focused on the phylogenetic analysis and selective evolution. Coevolution is the change that the conformation of one residue is interrupted by mutation and a compensatory change selected for in its interacting partner. Here, coevolutionary analysis of allophycocyanin, phycocyanin, and phycoerythrin and covariation analysis of linker peptides were performed. Coevolution analyses reveal that these sites are significantly correlated, showing strong evidence of the functional and structural importance of interactions among these residues. According to interprotein coevolution analysis, less interaction was found between PBPs and linker peptides. Our results also revealed the correlations between the coevolution and adaptive selection in PBS were not directly related, but probably demonstrated by the sites coupled under physical-chemical interactions.
机译：藻胆体是蓝细菌和红藻中的主要采光复合物。它由藻胆蛋白及其相关的连接肽组成，它们分别在光能的吸收和单向转移以及整个复杂系统的稳定性中起关键作用。以前关于PBP和接头肽之间进化的研究主要集中在系统发育分析和选择性进化上。协同进化是指一个残基的构象被突变和在其相互作用伴侣中选择的补偿性突变所中断的变化。在此，进行了藻蓝蛋白，藻蓝蛋白和藻红蛋白的协同进化分析以及接头肽的协变分析。协同进化分析显示，这些位点之间存在显着相关性，显示了这些残基之间相互作用的功能和结构重要性的有力证据。根据蛋白间协同进化分析，发现PBP与接头肽之间的相互作用较少。我们的研究结果还揭示了PBS中协同进化与适应选择之间的相关性并不直接相关，而可能由物理化学相互作用下耦合的位点所证实。

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