Identification of Hypoglycemia in Mice as a Surrogate Marker of Ricin Toxicosis

Pincus Seth H.; nbsp; Eng Leta; Cooke Corrie L.; Maddaloni Massimo

首页> 外文期刊>Comparative Medicine >Identification of Hypoglycemia in Mice as a Surrogate Marker of Ricin Toxicosis

【24h】

Identification of Hypoglycemia in Mice as a Surrogate Marker of Ricin Toxicosis

机译：小鼠低血糖的鉴定是蓖麻毒素中毒的替代标志

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Purpose:Inanefforttodevelopanon-lethalmodelofricintoxicosis,westudiedthebiochemicaleffectsoftheadministrationofricininmice.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Micereceivedanintraperitonealinjectionofricintoxin,afterwhichapanelof21biochemicalparameterswasdetermined.Effectofricinadministrationonbloodglucoseconcentrationwasstudiedingreaterdetail.Todeterminewhetherresultsofbiochemicalanalysescorrelatedwiththerapeuticmanipulationsknowntoprotectagainstricintoxicosis,theeffectofimmunizationonbloodglucosevaluesafterricinadministrationwasstudied.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Ofthebiochemicalparametersstudied,onlybloodglucoseandamylasevalueswereaffectedbyricinadministration.Becausebloodglucoseconcentrationcanbeeasilyandinstantaneouslymeasuredon25to50#59157;lofblood,usinghandheldinstruments,thisparameterwasfurtherevaluated.Adose-andtime-relateddecreaseinbloodglucoseconcentrationwasdocumented.Miceimmunizedwithricinhadsmallerchangesinbloodglucoseconcentrationthandidnon-immunizedanimalsafterricinadministration.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusion:Bloodglucoseconcentrationmaybeusedasasurrogateforlethalchallengeasameasureofricintoxicosisafteritssystemicadministration.

机译：目的：Inanefforttodevelopanon-lethalmodelofricintoxicosis，westudiedthebiochemicaleffectsoftheadministrationofricininmice 方法：Micereceivedanintraperitonealinjectionofricintoxin，afterwhichapanelof21biochemicalparameterswasdetermined.Effectofricinadministrationonbloodglucoseconcentrationwasstudiedingreaterdetail.Todeterminewhetherresultsofbiochemicalanalysescorrelatedwiththerapeuticmanipulationsknowntoprotectagainstricintoxicosis，theeffectofimmunizationonbloodglucosevaluesafterricinadministrationwasstudied 结果：研究的生化参数中，只有血液葡萄糖葡萄糖水合酶的值会受到ricin管理的影响。因为血液葡萄糖的浓度可以轻易地和集中地测量到25到50＃59157的血糖值之间的亲和力，然后通过手持仪器将其重新计算，然后用手持式仪器将其分装得很低。结论：血液葡萄糖浓度可能在系统管理后用于替代致命的挑战性措施。

著录项

来源
《Comparative Medicine》 |2002年第6期|共页
作者
Pincus Seth H.; nbsp; Eng Leta; Cooke Corrie L.; Maddaloni Massimo;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类畜牧、动物医学、狩猎、蚕、蜂;
关键词

相似文献

外文文献
中文文献
专利

1. Identification of Hypoglycemia in mice as a surrogate marker of ricin toxicosis [J] . Pincus SH, Eng L, Cooke CL, Comparative Medicine . 2002,第6期

机译：鉴定小鼠低血糖是蓖麻毒素中毒的替代指标
2. Identification of insulin-like growth factor binding protein-2 as a biochemical surrogate marker for the in vivo effects of recombinant human insulin-like growth factor-1 in mice. [J] . Bhat RV, Engber TM, Zhu Y, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第1期

机译：胰岛素样生长因子结合蛋白2的鉴定作为重组人胰岛素样生长因子1在小鼠体内作用的生化替代标志物。
3. Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice. [J] . McKay J. A, Long Xie Harris S, Wong Y. K, Molecular Nutrition and Food Research . 2011,第7期

机译：血液可作为组织特异性DNA甲基化和产后雌性小鼠中叶酸消耗引起的变化的替代标记。
4. GC-MS Analysis of Carbohydate and Fatty Acid Marker Abundance in Ricin Toxin Preparations [C] . Kathryn C. Antolick, Heather A. Colburn, David S. Wunschel, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：蓖麻毒素毒素制剂中碳水化合物和脂肪酸标志性的GC-MS分析
5. A New Transduction Mechanism for Detecting Biological Radiation Damage Using Metabolic Response of Yeast as a Surrogate Marker [D] . Yoon, Chang Keun. 2017

机译：利用酵母的代谢反应作为替代指标检测生物辐射损伤的新转导机制
6. Identification of Neutrophil Activation Markers as Novel Surrogate Markers of CF Lung Disease [O] . Timo Rath, Lisa Zwaschka, Lisa Hage, -1

机译：中性粒细胞激活标志物的鉴定作为CF肺疾病的新型替代标志物
7. Fatal Ricin Toxicosis in a Puppy Confirmed by Liquid Chromatography/Mass Spectrometry when Using Ricinine as a Marker [O] . Pamela Mouser, Michael S. Filigenzi, Birgit Puschner, 2007

机译：致命蓖麻毒素在使用蓖麻层/质谱时确认的小狗在使用蓖麻素/质谱时确认
8. Identification of a Surrogate Marker for Infection in the African Green Monkey Model of Inhalation Anthrax [R] . Rossi, C. A., Ulrich, M., Norris, S., 2008

机译：非洲绿猴吸入炭疽模型中感染的替代标记的鉴定

Identification of Hypoglycemia in Mice as a Surrogate Marker of Ricin Toxicosis

摘要

著录项

相似文献

相关主题

期刊订阅