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首页> 外文期刊>Biology Open >The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype
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The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype

机译：蛋清抗微生物剂的隐藏功能：抗虫卵蛋白对禽类胚胎存活和孵化表型的体重依赖性

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Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We tested the effect of experimentally increased egg white avidin concentration (AVIDIN+) on hatching success, chick morphology, post-hatching growth performance and innate immune function in a model bird, Japanese quail (Coturnix japonica). Probability of embryo survival in the late embryonic phase increased with increasing egg weight in control eggs, but not in AVIDIN+ eggs. Chicks hatching from lighter AVIDIN+ eggs had a shorter tarsus than chicks hatching from heavier AVIDIN+ eggs. This suggests that an increase in egg white avidin favours embryo survival in lighter eggs during late embryogenesis, but at the expense of reduced structural body size. Plasma complement activity in 6-day-old AVIDIN+ chicks decreased with increasing body mass and tarsus length; the opposite was observed in control chicks, implying that the later post-hatching innate immune function of larger chicks was compromised by an increase in egg white avidin concentration. Here, we document an important role of egg white antimicrobials in maintenance of embryo viability, avian hatchling morphology and immune phenotype.
机译：抗生物素蛋白是一种关键的蛋清抗菌蛋白，对生物素具有重要的结合能力，生物素是一种必需的生长和免疫细胞前体。因此，虽然对孵化表型的影响尚不充分，但仍被认为具有明显的影响。我们测试了实验性增加的蛋清抗生物素蛋白浓度（AVIDIN +）对模型鸟日本鹌鹑（Coturnix japonica）的孵化成功率，雏鸡形态，孵化后生长性能和先天免疫功能的影响。胚胎后期胚胎存活的可能性随着对照鸡蛋中蛋重的增加而增加，但不包括AVIDIN +鸡蛋中的。从较轻的AVIDIN +卵孵化的雏鸡的节短于从较重的AVIDIN +卵孵化的雏鸟。这表明蛋清抗生物素蛋白的增加有利于后期胚胎发生期间较轻卵子的胚胎存活，但以减小结构体尺寸为代价。 6天大的AVIDIN +雏鸡的血浆补体活性随体重和长度的增加而降低。在对照雏鸡中观察到相反的情况，这表明较大的雏鸡在孵化后的先天免疫功能受到蛋清抗生物素蛋白浓度增加的损害。在这里，我们记录了蛋清抗菌素在维持胚胎活力，禽孵化形态和免疫表型中的重要作用。

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