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首页> 外文期刊>Clinical & developmental immunology. >IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection
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IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection

机译：IL-17A和Th17细胞在肺炎症中：Th17细胞分化和IL-17R信号在宿主抗感染防御中的作用的更新

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摘要

The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway's immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia ( K. pneumonia ) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection.
机译：在各种感染和自身免疫模型中已经证明了Th17细胞和白介素（IL-）17A信号传导在宿主防御和疾病发展中的重要性。大量研究表明，Th17细胞及其标志性细胞因子IL-17A对气道针对各种细菌和真菌感染的免疫反应至关重要。参与Th17分化的细胞因子（如IL-23）在控制克雷伯菌肺炎（K. pneumonia）感染中起关键作用。 IL-17A通过诱导抗微生物蛋白，细胞因子和趋化因子的表达，作用于感染组织中的非免疫细胞，从而增强先天免疫。 IL-17受体（IL-17R）表达不足的小鼠易受多种病原体感染。在这篇综述中，我们总结了揭示Th17细胞分化，IL-17A / IL-17R信号传导背后的机制以及IL-17A在肺部感染中的重要性的最新进展。

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