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首页> 外文期刊>Clinical & developmental immunology. >Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis
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Baicalin Inhibits IL-17-Mediated Joint Inflammation in Murine Adjuvant-Induced Arthritis

机译：黄ical苷抑制小鼠佐剂诱导的关节炎中IL-17介导的关节发炎。

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摘要

T-helper-17 (Th17) cells are implicated in a number of inflammatory disorders including rheumatoid arthritis. Antagonism of Th17 cells is a treatment option for arthritis. Here, we report that Baicalin, a compound isolated from the Chinese herb Huangqin ( Scutellaria baicalensis Georgi), relieved ankle swelling and protected the joint against inflammatory destruction in a murine adjuvant-induced arthritis model. Baicalin inhibited splenic Th17 cell population expansion in vivo . Baicalin prevented interleukin- (IL-) 17-mediated lymphocyte adhesion to cultured synoviocytes. Baicalin also blocked IL-17-induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes. Collectively, these findings suggest that Baicalin downregulates the joint inflammation caused by IL-17, which is likely produced by an expanded population of splenic Th17 cells in experimental arthritis. Baicalin might be a promising novel therapeutic agent for treating rheumatoid arthritis in humans.
机译：T-helper-17（Th17）细胞与多种炎性疾病有关，包括类风湿关节炎。 Th17细胞的拮抗作用是关节炎的一种治疗选择。在这里，我们报道了黄ical苷，一种从中草药黄琴（黄cut（Scutellaria baicalensis Georgi）中分离出的化合物），在小鼠佐剂诱发的关节炎模型中缓解了脚踝肿胀并保护了关节免受炎性破坏。黄in苷抑制脾脏Th17细胞的体内扩增。黄ical苷可阻止白介素（IL-）17介导的淋巴细胞粘附至培养的滑膜细胞。黄ical素还阻断了IL-17诱导的滑膜细胞中细胞间粘附分子1，血管细胞粘附分子1，IL-6和肿瘤坏死因子-αmRNA的表达。总的来说，这些发现表明黄ical苷下调了由IL-17引起的关节炎症，这可能是由于实验性关节炎中脾脏Th17细胞数量的增加而引起的。黄ical苷可能是治疗人类类风湿关节炎的一种有前途的新型治疗剂。

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