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首页> 外文期刊>Clinical & developmental immunology. >The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection
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The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection

机译：转录因子T-bet / GATA3比值在预测抗体介导的排斥反应中的诊断价值

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Background . Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T-cell-mediated rejection (TCMR). Methods . We compared the intraglomerular T-bet/GATA3 ratio in ABMR and TCMR. The intragraft expression of T-bet and GATA3 was studied via immunohistochemistry. The correlation of the diagnosis of AMR with the ratio of T-bet/GATA3 was examined. Results . Both intraglomerular T-bet- and GATA3-expressing cells were increased during acute rejection. T-bet/GATA3>1 was strongly correlated with ABMR (93.3% versus 18.2%). The incidence of positive HLA-I/II antibodies and glomerulitis is significantly higher in T-bet/GATA3>1 group ( P < 0.001, 0.013, resp.). The scores of peritubular capillary inflammation and glomerulitis were also higher in T-bet/GATA3>1 group ( P = 0.052, P < 0.001, resp.). Nevertheless, T-bet/GATA3>1 is also correlated with C4d-negative ABMR and resistance to steroid treatment. Compared with C4d deposition, T-bet/GATA3>1 had a slight lower (90% versus 100%) specificity but a much higher (87.5% versus 68.8%) sensitivity. Conclusion . Our data suggested that intraglomerular predominance of T-bet over GATA3 might be used as diagnosis maker of ABMR in addition to C4d, especially in C4d-negative cases.
机译：背景 。先前的数据显示，肾小球内T-bet或GATA3的优势与排斥的不同机制相关，这表明T-bet / GATA3的比率可用于区分抗体介导的排斥（ABMR）和T细胞介导的排斥（TCMR）。方法 。我们比较了ABMR和TCMR中肾小球内T-bet / GATA3的比率。通过免疫组织化学研究了T-bet和GATA3在移植物中的表达。检查了AMR诊断与T-bet / GATA3比率的相关性。结果。在急性排斥过程中，肾小球内T-bet和GATA3表达细胞均增加。 T-bet / GATA3> 1与ABMR密切相关（93.3％对18.2％）。在T-bet / GATA3> 1组中，阳性HLA-I / II抗体和肾小球炎的发生率显着更高（P <0.001，0.013，分别）。 T-bet / GATA3> 1组的肾小管周围毛细血管炎和肾小球炎评分也更高（P = 0.052，P <0.001，分别）。然而，T-bet / GATA3> 1也与C4d阴性ABMR和对类固醇治疗的抗性相关。与C4d沉积相比，T-bet / GATA3> 1的特异性稍低（90％对100％），但敏感性高得多（87.5％对68.8％）。结论。我们的数据表明，除了C4d之外，T-bet在GATA3上的肾小球优势还可以用作ABMR的诊断工具，尤其是在C4d阴性病例中。

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