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首页> 外文期刊>Clinical & developmental immunology. >Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund's Adjuvant
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Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund's Adjuvant

机译：包含霍乱毒素B亚基-自身抗原融合蛋白和完全弗氏佐剂的多组分疫苗可持久抑制1型糖尿病。

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摘要

Data presented here demonstrate multifunctional vaccination strategies that harness vaccinia virus mediated delivery of a gene encoding an immunoenhanced diabetes autoantigen in combination with complete Freund's adjuvant (CFA) that can maintain safe and durable immunologic homeostasis in NOD mice. Systemic coinoculation of prediabetic mice with recombinant vaccinia virus rVV-CTB::GAD and undiluted or 10-fold diluted CFA demonstrated a significant decrease in hyperglycemia and pancreatic islet inflammation in comparison with control animals during 17–61 and 17–105 weeks of age, respectively. Synergy in these beneficial effects was observed during 43–61 and 61–105 wks of age, respectively. Inflammatory cytokine and chemokine levels in GAD-stimulated splenocytes isolated from vaccinated mice were generally lower than those detected in unvaccinated mice. The overall health and humoral immune responses of the vaccinated animals remained normal throughout the duration of the experiments.
机译：此处提供的数据证明了多功能疫苗接种策略，该策略利用牛痘病毒介导的编码免疫增强型糖尿病自身抗原的基因与完全弗氏佐剂（CFA）结合，可以在NOD小鼠中维持安全和持久的免疫稳态。与重组动物相比，重组牛痘病毒rVV-CTB :: GAD和未稀释或稀释10倍的CFA对糖尿病前期小鼠进行全身共接种表明，与对照组相比，高血糖和胰腺胰岛炎症显着降低，分别。这些有益作用的协同作用分别在43-61周龄和61-105周龄之间观察到。从接种疫苗的小鼠中分离出的GAD刺激的脾细胞中的炎症细胞因子和趋化因子水平通常低于未接种疫苗的小鼠中检测到的水平。在整个实验过程中，接种动物的总体健康状况和体液免疫反应均保持正常。

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